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Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction.

Publication ,  Journal Article
McCarthy, JJ; Somji, A; Weiss, LA; Steffy, B; Vega, R; Barrett-Connor, E; Talavera, G; Glynne, R
Published in: J Clin Endocrinol Metab
May 2009

BACKGROUND: Genetic variation in diabetes-associated genes cumulatively explain little of the overall heritability of this trait. We sought to determine whether polymorphisms of the scavenger receptor class B, member I (SCARB1), an estrogen-regulated chromosome 12q24 positional candidate diabetes gene, were associated with type 2 diabetes or insulin resistance in a sex-specific fashion. METHODS: We evaluated 34 haplotype-tagged single-nucleotide polymorphisms (SNPs) of SCARB1 for their association with type 2 diabetes and measures of insulin resistance in two populations: a clinic-based sample of 444 Mexican-American women from Proyecto SALSA and a community-based sample of 830 white women from the Rancho Bernardo Study. RESULTS: We identified significant associations between a tagged SNP in intron 9, rs9919713, and fasting glucose in the SALSA population (P = 2.3 x 10(-4)). In the Rancho Bernardo Study, the same SNP also showed significant association with the related traits homeostasis model assessment for insulin resistance (P = 3.0 x 10(-4)), fasting glucose (P = 1.1 x 10(-3)), and type 2 diabetes (P = 9.0 x 10(-3)). In men from the Rancho Bernardo population, the opposite effect was found (genotype by sex interaction in the Rancho Bernardo population P < 10(-3) for insulin resistance). CONCLUSIONS: Our data support an association between SCARB1 variants and insulin resistance, especially in women, with evidence of significant gene by sex interaction. These findings warrant further investigation in additional populations and prompt exploration of a role for SR-BI in the development of insulin resistance.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

May 2009

Volume

94

Issue

5

Start / End Page

1789 / 1796

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Scavenger Receptors, Class B
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Middle Aged
  • Mexican Americans
  • Male
  • Insulin Resistance
  • Humans
  • Homeostasis
 

Citation

APA
Chicago
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MLA
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McCarthy, J. J., Somji, A., Weiss, L. A., Steffy, B., Vega, R., Barrett-Connor, E., … Glynne, R. (2009). Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction. J Clin Endocrinol Metab, 94(5), 1789–1796. https://doi.org/10.1210/jc.2008-2800
McCarthy, Jeanette J., Aleefia Somji, Lauren A. Weiss, Brian Steffy, Raquel Vega, Elizabeth Barrett-Connor, Gregory Talavera, and Richard Glynne. “Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction.J Clin Endocrinol Metab 94, no. 5 (May 2009): 1789–96. https://doi.org/10.1210/jc.2008-2800.
McCarthy JJ, Somji A, Weiss LA, Steffy B, Vega R, Barrett-Connor E, et al. Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction. J Clin Endocrinol Metab. 2009 May;94(5):1789–96.
McCarthy, Jeanette J., et al. “Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction.J Clin Endocrinol Metab, vol. 94, no. 5, May 2009, pp. 1789–96. Pubmed, doi:10.1210/jc.2008-2800.
McCarthy JJ, Somji A, Weiss LA, Steffy B, Vega R, Barrett-Connor E, Talavera G, Glynne R. Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction. J Clin Endocrinol Metab. 2009 May;94(5):1789–1796.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

May 2009

Volume

94

Issue

5

Start / End Page

1789 / 1796

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Scavenger Receptors, Class B
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Middle Aged
  • Mexican Americans
  • Male
  • Insulin Resistance
  • Humans
  • Homeostasis