B cell loss leading to remission in severe systemic lupus erythematosus.
Publication
, Journal Article
Tarrant, TK; Frazer, DH; Aya-Ay, JP; Patel, DD
Published in: J Rheumatol
February 2003
Systemic lupus erythematosus (SLE) pathogenesis is mediated in part by autoantibodies. We describe a patient with central nervous system lupus who developed a loss of B cells with associated hypogammaglobulinemia and sinopulmonary infections requiring intravenous immunoglobulin. The SLE went into complete remission. Of 18 reported patients with SLE developing persistent hypogammaglobulinemia, only 5 patients including ours had a nearly complete loss of circulating B cells. Of those whose SLE and B cell status was reported, 5/5 with B cell loss and 1/10 without B cell loss experienced a durable response of SLE (p = 0.002). These cases illustrate that B cell ablative therapies may have efficacy for SLE.
Duke Scholars
Published In
J Rheumatol
ISSN
0315-162X
Publication Date
February 2003
Volume
30
Issue
2
Start / End Page
412 / 414
Location
Canada
Related Subject Headings
- Severity of Illness Index
- Remission Induction
- Lymphocyte Count
- Lupus Erythematosus, Systemic
- Immunosuppressive Agents
- Immunoglobulins, Intravenous
- Humans
- Female
- B-Lymphocytes
- Arthritis & Rheumatology
Citation
APA
Chicago
ICMJE
MLA
NLM
Tarrant, T. K., Frazer, D. H., Aya-Ay, J. P., & Patel, D. D. (2003). B cell loss leading to remission in severe systemic lupus erythematosus. J Rheumatol, 30(2), 412–414.
Tarrant, Teresa K., D Hugh Frazer, James P. Aya-Ay, and Dhavalkumar D. Patel. “B cell loss leading to remission in severe systemic lupus erythematosus.” J Rheumatol 30, no. 2 (February 2003): 412–14.
Tarrant TK, Frazer DH, Aya-Ay JP, Patel DD. B cell loss leading to remission in severe systemic lupus erythematosus. J Rheumatol. 2003 Feb;30(2):412–4.
Tarrant, Teresa K., et al. “B cell loss leading to remission in severe systemic lupus erythematosus.” J Rheumatol, vol. 30, no. 2, Feb. 2003, pp. 412–14.
Tarrant TK, Frazer DH, Aya-Ay JP, Patel DD. B cell loss leading to remission in severe systemic lupus erythematosus. J Rheumatol. 2003 Feb;30(2):412–414.
Published In
J Rheumatol
ISSN
0315-162X
Publication Date
February 2003
Volume
30
Issue
2
Start / End Page
412 / 414
Location
Canada
Related Subject Headings
- Severity of Illness Index
- Remission Induction
- Lymphocyte Count
- Lupus Erythematosus, Systemic
- Immunosuppressive Agents
- Immunoglobulins, Intravenous
- Humans
- Female
- B-Lymphocytes
- Arthritis & Rheumatology