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A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer.

Publication ,  Journal Article
Patel, PR; Yoo, DS; Niibe, Y; Urbanic, JJ; Salama, JK
Published in: Pulm Med
2012

Metastatic non-small cell lung cancer (NSCLC) carries a dismal prognosis. Clinical evidence suggests the existence of an intermediate, or oligometastatic, state when metastases are limited in number and/or location. In addition, following initial curative therapy, many patients present with limited metastatic disease, or oligo-recurrence. Metastasis-directed, anti-cancer therapies may benefit these patients. A growing evidence-base supports the use of hypofractionated, image-guided radiotherapy (HIGRT) for a variety of malignant conditions including inoperable stage I NSCLC and many metastatic sites. When surgical resection is not possible, HIGRT offers an effective alternative for local treatment of limited metastatic disease. Early studies have produced promising results when HIGRT was delivered to all known sites of disease in patients with oligometastatic/oligo-recurrent NSCLC. In a population of patients formerly considered rapidly terminal, these studies report five year overall survival rates of 13-22%. HIGRT for metastatic NSCLC warrants further study. We call for large, intergroup, and even international randomized trials incorporating HIGRT and other metastasis-directed therapies into the treatment of patients with oligometastatic/oligo-recurrent NSCLC.

Duke Scholars

Published In

Pulm Med

DOI

EISSN

2090-1844

Publication Date

2012

Volume

2012

Start / End Page

480961

Location

Egypt
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, P. R., Yoo, D. S., Niibe, Y., Urbanic, J. J., & Salama, J. K. (2012). A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer. Pulm Med, 2012, 480961. https://doi.org/10.1155/2012/480961
Patel, Pretesh R., David S. Yoo, Yuzuru Niibe, James J. Urbanic, and Joseph K. Salama. “A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer.Pulm Med 2012 (2012): 480961. https://doi.org/10.1155/2012/480961.
Patel PR, Yoo DS, Niibe Y, Urbanic JJ, Salama JK. A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer. Pulm Med. 2012;2012:480961.
Patel, Pretesh R., et al. “A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer.Pulm Med, vol. 2012, 2012, p. 480961. Pubmed, doi:10.1155/2012/480961.
Patel PR, Yoo DS, Niibe Y, Urbanic JJ, Salama JK. A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer. Pulm Med. 2012;2012:480961.

Published In

Pulm Med

DOI

EISSN

2090-1844

Publication Date

2012

Volume

2012

Start / End Page

480961

Location

Egypt