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Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study.

Publication ,  Journal Article
Goetz, EL; Hariri, AR; Pizzagalli, DA; Strauman, TJ
Published in: Biology of mood & anxiety disorders
February 2013

Recent studies implicate individual differences in regulatory focus as contributing to self-regulatory dysfunction, particularly not responding to positive outcomes. How such individual differences emerge, however, is unclear. We conducted a proof-of-concept study to examine the moderating effects of genetically driven variation in dopamine signaling, a key modulator of neural reward circuits, on the association between regulatory focus and reward cue responsiveness.Healthy Caucasians (N=59) completed a measure of chronic regulatory focus and a probabilistic reward task. A common functional genetic polymorphism impacting prefrontal dopamine signaling (COMT rs4680) was evaluated.Response bias, the participants' propensity to modulate behavior as a function of reward, was predicted by an interaction of regulatory focus and COMT genotype. Specifically, self-perceived success at achieving promotion goals predicted total response bias, but only for individuals with the COMT genotype (Val/Val) associated with relatively increased phasic dopamine signaling and cognitive flexibility.The combination of success in promotion goal pursuit and Val/Val genotype appears to facilitate responding to reward opportunities in the environment. This study is among the first to integrate an assessment of self-regulatory style with an examination of genetic variability that underlies responsiveness to positive outcomes in goal pursuit.

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Published In

Biology of mood & anxiety disorders

DOI

EISSN

2045-5380

ISSN

2045-5380

Publication Date

February 2013

Volume

3

Issue

1

Start / End Page

3
 

Citation

APA
Chicago
ICMJE
MLA
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Goetz, E. L., Hariri, A. R., Pizzagalli, D. A., & Strauman, T. J. (2013). Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study. Biology of Mood & Anxiety Disorders, 3(1), 3. https://doi.org/10.1186/2045-5380-3-3
Goetz, Elena L., Ahmad R. Hariri, Diego A. Pizzagalli, and Timothy J. Strauman. “Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study.Biology of Mood & Anxiety Disorders 3, no. 1 (February 2013): 3. https://doi.org/10.1186/2045-5380-3-3.
Goetz EL, Hariri AR, Pizzagalli DA, Strauman TJ. Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study. Biology of mood & anxiety disorders. 2013 Feb;3(1):3.
Goetz, Elena L., et al. “Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study.Biology of Mood & Anxiety Disorders, vol. 3, no. 1, Feb. 2013, p. 3. Epmc, doi:10.1186/2045-5380-3-3.
Goetz EL, Hariri AR, Pizzagalli DA, Strauman TJ. Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study. Biology of mood & anxiety disorders. 2013 Feb;3(1):3.
Journal cover image

Published In

Biology of mood & anxiety disorders

DOI

EISSN

2045-5380

ISSN

2045-5380

Publication Date

February 2013

Volume

3

Issue

1

Start / End Page

3