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The significance of hydrosalpinx in in vitro fertilization.

Publication ,  Journal Article
Nackley, AC; Muasher, SJ
Published in: Fertil Steril
March 1998

OBJECTIVE: To review the effects of hydrosalpinx on IVF/ET and the role of salpingectomy. DESIGN: The literature on hydrosalpinx, IVF/ET, embryotoxicity, and salpingectomy for hydrosalpinx was identified through MEDLINE searches and reviewed. RESULT(S): Hydrosalpinx has been associated with poor fertility prognosis. IVF/ET is a better alternative to tubal surgery for those patients with severe distal tubal disease, and it is also more cost effective. However, the presence of hydrosalpinx has a negative effect on IVF/ET by decreasing the pregnancy rates and implantation rates compared with patients undergoing IVF/ET for tubal disease but without hydrosalpinx. The hydrosalpingeal fluid has been demonstrated to be embryotoxic to developing embryos, thus leading to increased early pregnancy losses. Poor endometrial receptivity has also been demonstrated in the presence of hydrosalpinges. Removal of the hydrosalpinges leads to improved IVF/ET rates comparable to those patients without hydrosalpinx. Therefore, salpingectomy has been recommended for patients with hydrosalpinx who will be undergoing IVF/ET. CONCLUSION(S): The presence of hydrosalpinx has a negative effect on IVF/ET because of the suspected embryotoxicity of the hydrosalpingeal fluid. Surgical removal of the hydrosalpinx has been shown to improve IVF/ET rates.

Duke Scholars

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

March 1998

Volume

69

Issue

3

Start / End Page

373 / 384

Location

United States

Related Subject Headings

  • Prognosis
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Infertility, Female
  • Humans
  • Fetal Death
  • Fertilization in Vitro
  • Female
  • Fallopian Tube Diseases
  • Exudates and Transudates
 

Citation

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Nackley, A. C., & Muasher, S. J. (1998). The significance of hydrosalpinx in in vitro fertilization. Fertil Steril, 69(3), 373–384. https://doi.org/10.1016/s0015-0282(97)00484-6
Nackley, A. C., and S. J. Muasher. “The significance of hydrosalpinx in in vitro fertilization.Fertil Steril 69, no. 3 (March 1998): 373–84. https://doi.org/10.1016/s0015-0282(97)00484-6.
Nackley AC, Muasher SJ. The significance of hydrosalpinx in in vitro fertilization. Fertil Steril. 1998 Mar;69(3):373–84.
Nackley, A. C., and S. J. Muasher. “The significance of hydrosalpinx in in vitro fertilization.Fertil Steril, vol. 69, no. 3, Mar. 1998, pp. 373–84. Pubmed, doi:10.1016/s0015-0282(97)00484-6.
Nackley AC, Muasher SJ. The significance of hydrosalpinx in in vitro fertilization. Fertil Steril. 1998 Mar;69(3):373–384.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

March 1998

Volume

69

Issue

3

Start / End Page

373 / 384

Location

United States

Related Subject Headings

  • Prognosis
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Infertility, Female
  • Humans
  • Fetal Death
  • Fertilization in Vitro
  • Female
  • Fallopian Tube Diseases
  • Exudates and Transudates