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Platelet uptake of the pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine.

Publication ,  Journal Article
Feldman, JM; Frankel, N; Coleman, RE
Published in: Metabolism
May 1984

The pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine (131I-MIBG) was concentrated in the platelets of ten subjects undergoing scans for suspected pheochromocytomas. In vitro studies also demonstrated that 131I-MIBG was concentrated in platelets. In contrast to serotonin, which had maximum in vitro platelet uptake of one hour, the peak in vitro platelet uptake of 131I-MIBG did not occur until six hours. In vitro platelet 131I-MIBG uptake was decreased by 79% to 98% following the neuronal-uptake-blocking agent imipramine. These studies suggest that pheochromocytomas take up 131I-MIBG by a neuronal-pump mechanism. Further studies to determine if 131I-MIBG is taken up by other tumors with a neuronal-pump mechanism, such as carcinoid tumors, will be valuable.

Duke Scholars

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

May 1984

Volume

33

Issue

5

Start / End Page

397 / 399

Location

United States

Related Subject Headings

  • Time Factors
  • Serotonin
  • Radionuclide Imaging
  • Pheochromocytoma
  • Middle Aged
  • Male
  • Iodobenzenes
  • In Vitro Techniques
  • Imipramine
  • Humans
 

Citation

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Chicago
ICMJE
MLA
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Feldman, J. M., Frankel, N., & Coleman, R. E. (1984). Platelet uptake of the pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine. Metabolism, 33(5), 397–399. https://doi.org/10.1016/0026-0495(84)90135-5
Feldman, J. M., N. Frankel, and R. E. Coleman. “Platelet uptake of the pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine.Metabolism 33, no. 5 (May 1984): 397–99. https://doi.org/10.1016/0026-0495(84)90135-5.
Feldman JM, Frankel N, Coleman RE. Platelet uptake of the pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine. Metabolism. 1984 May;33(5):397–9.
Feldman, J. M., et al. “Platelet uptake of the pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine.Metabolism, vol. 33, no. 5, May 1984, pp. 397–99. Pubmed, doi:10.1016/0026-0495(84)90135-5.
Feldman JM, Frankel N, Coleman RE. Platelet uptake of the pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine. Metabolism. 1984 May;33(5):397–399.
Journal cover image

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

May 1984

Volume

33

Issue

5

Start / End Page

397 / 399

Location

United States

Related Subject Headings

  • Time Factors
  • Serotonin
  • Radionuclide Imaging
  • Pheochromocytoma
  • Middle Aged
  • Male
  • Iodobenzenes
  • In Vitro Techniques
  • Imipramine
  • Humans