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A history of the concept of atypical depression.

Publication ,  Conference
Davidson, JRT
Published in: J Clin Psychiatry
2007

The term atypical depression as a preferentially monoamine oxidase inhibitor (MAOI)-responsive state was first introduced by West and Dally in 1959. Further characterization of this syndrome and its responsiveness to antidepressants came to occupy the attention of many psychopharmacologists for the next 30 years. Different portrayals of atypical depression have emerged, for example, nonendogenous depression, phobic anxiety with secondary depression, vegetative reversal, rejection-sensitivity, and depression with severe chronic pain. Consistency across or within types has been unimpressive, and no coherent single type of depression can yet be said to be "atypical." In successfully demonstrating superiority of MAOI drugs to tricyclics, the Columbia (or DSM-IV) criteria have established their utility and become widely adopted, but other criteria have also passed this test. In this "post-MAOI" era, no novel compound or group of drugs has been clearly shown to have good efficacy in atypical depression, leaving the treatment of atypical depression as an unmet need.

Duke Scholars

Published In

J Clin Psychiatry

EISSN

1555-2101

Publication Date

2007

Volume

68 Suppl 3

Start / End Page

10 / 15

Location

United States

Related Subject Headings

  • Syndrome
  • Psychiatry
  • Pain
  • Monoamine Oxidase Inhibitors
  • Humans
  • History, 20th Century
  • Diagnostic and Statistical Manual of Mental Disorders
  • Depressive Disorder
  • Chronic Disease
  • Bipolar Disorder
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davidson, J. R. T. (2007). A history of the concept of atypical depression. In J Clin Psychiatry (Vol. 68 Suppl 3, pp. 10–15). United States.
Davidson, Jonathan R. T. “A history of the concept of atypical depression.” In J Clin Psychiatry, 68 Suppl 3:10–15, 2007.
Davidson JRT. A history of the concept of atypical depression. In: J Clin Psychiatry. 2007. p. 10–5.
Davidson, Jonathan R. T. “A history of the concept of atypical depression.J Clin Psychiatry, vol. 68 Suppl 3, 2007, pp. 10–15.
Davidson JRT. A history of the concept of atypical depression. J Clin Psychiatry. 2007. p. 10–15.

Published In

J Clin Psychiatry

EISSN

1555-2101

Publication Date

2007

Volume

68 Suppl 3

Start / End Page

10 / 15

Location

United States

Related Subject Headings

  • Syndrome
  • Psychiatry
  • Pain
  • Monoamine Oxidase Inhibitors
  • Humans
  • History, 20th Century
  • Diagnostic and Statistical Manual of Mental Disorders
  • Depressive Disorder
  • Chronic Disease
  • Bipolar Disorder