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Effect of apolipoproteins on the induction of hepatic steatosis in rats.

Publication ,  Journal Article
Quarfordt, SH; Shelburne, FA; Meyers, W; Jakoi, L; Hanks, J
Published in: Gastroenterology
January 1981

The incorporation of apolipoprotein E isolated from human very low density lipoproteins on a triglyceride emulsion produced a substantial increment in hepatic triglyceride after 1 h of in vitro perfusion through the isolated liver of a fasted rat. Both gross and microscopic morphology confirmed a substantial steatosis. Perfusions with triglyceride emulsions which contained no apoipoproteins resulted in a modest increment in hepatic triglyceride although considerably less than emulsions with the E protein, and no morphologic features of steatosis. The steatosis induced in the in vitro perfused fasted livers by the emulsions with E protein could be prevented when CIII-1 apoprotein was also incorporated on the emulsion. A fed rat liver perfused with the E-enriched emulsion accumulated significantly less triglyceride than the fasted preparation. These data suggest that the apoprotein patterns of the plasma triglyceride-rich lipoproteins are of considerable importance for the partition of triglyceride between liver and plasma.

Duke Scholars

Published In

Gastroenterology

ISSN

0016-5085

Publication Date

January 1981

Volume

80

Issue

1

Start / End Page

149 / 153

Location

United States

Related Subject Headings

  • Triglycerides
  • Rats
  • Perfusion
  • Male
  • Liver
  • Gastroenterology & Hepatology
  • Fatty Liver
  • Fasting
  • Apolipoproteins E
  • Apolipoproteins C
 

Citation

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Quarfordt, S. H., Shelburne, F. A., Meyers, W., Jakoi, L., & Hanks, J. (1981). Effect of apolipoproteins on the induction of hepatic steatosis in rats. Gastroenterology, 80(1), 149–153.
Quarfordt, S. H., F. A. Shelburne, W. Meyers, L. Jakoi, and J. Hanks. “Effect of apolipoproteins on the induction of hepatic steatosis in rats.Gastroenterology 80, no. 1 (January 1981): 149–53.
Quarfordt SH, Shelburne FA, Meyers W, Jakoi L, Hanks J. Effect of apolipoproteins on the induction of hepatic steatosis in rats. Gastroenterology. 1981 Jan;80(1):149–53.
Quarfordt, S. H., et al. “Effect of apolipoproteins on the induction of hepatic steatosis in rats.Gastroenterology, vol. 80, no. 1, Jan. 1981, pp. 149–53.
Quarfordt SH, Shelburne FA, Meyers W, Jakoi L, Hanks J. Effect of apolipoproteins on the induction of hepatic steatosis in rats. Gastroenterology. 1981 Jan;80(1):149–153.
Journal cover image

Published In

Gastroenterology

ISSN

0016-5085

Publication Date

January 1981

Volume

80

Issue

1

Start / End Page

149 / 153

Location

United States

Related Subject Headings

  • Triglycerides
  • Rats
  • Perfusion
  • Male
  • Liver
  • Gastroenterology & Hepatology
  • Fatty Liver
  • Fasting
  • Apolipoproteins E
  • Apolipoproteins C