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Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation.

Publication ,  Journal Article
Matza, LS; Phillips, GA; Revicki, DA; Ascher-Svanum, H; Malley, KG; Palsgrove, AC; Faries, DE; Stauffer, V; Kinon, BJ; Awad, AG; Keefe, RS; Naber, D
Published in: Patient Prefer Adherence
2012

INTRODUCTION: The Reasons for Antipsychotic Discontinuation Interview (RAD-I) was developed to assess patients' perceptions of reasons for discontinuing or continuing an antipsychotic. The current study examined reliability and validity of domain scores representing three factors contributing to these treatment decisions: treatment benefits, adverse events, and distal reasons other than direct effects of the medication. METHODS: Data were collected from patients with schizophrenia or schizoaffective disorder and their treating clinicians. For approximately 25% of patients, a second rater completed the RAD-I for assessment of inter-rater reliability. RESULTS: All patients (n = 121; 81 discontinuation, 40 continuation) reported at least one reason for discontinuation or continuation (mean = 2.8 reasons for discontinuation; 3.4 for continuation). Inter-rater reliability was supported (kappas = 0.63-1.0). Validity of the discontinuation domain scores was supported by associations with symptom measures (the Positive and Negative Syndrome Scale for Schizophrenia, the Clinical Global Impression - Schizophrenia Scale; r = 0.30 to 0.51; all P < 0.01), patients' primary reasons for discontinuation, and adverse events. However, the continuation domain scores were not significantly associated with these other indicators. DISCUSSION: Results support the reliability, convergent validity, and known-groups validity of the RAD-I for assessing patients' reasons for antipsychotic discontinuation. Further research is needed to examine validity of the RAD-I continuation section.

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Published In

Patient Prefer Adherence

DOI

EISSN

1177-889X

Publication Date

2012

Volume

6

Start / End Page

521 / 532

Location

New Zealand

Related Subject Headings

  • 4203 Health services and systems
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Matza, L. S., Phillips, G. A., Revicki, D. A., Ascher-Svanum, H., Malley, K. G., Palsgrove, A. C., … Naber, D. (2012). Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation. Patient Prefer Adherence, 6, 521–532. https://doi.org/10.2147/PPA.S25635
Matza, Louis S., Glenn A. Phillips, Dennis A. Revicki, Haya Ascher-Svanum, Karen G. Malley, Andrew C. Palsgrove, Douglas E. Faries, et al. “Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation.Patient Prefer Adherence 6 (2012): 521–32. https://doi.org/10.2147/PPA.S25635.
Matza LS, Phillips GA, Revicki DA, Ascher-Svanum H, Malley KG, Palsgrove AC, et al. Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation. Patient Prefer Adherence. 2012;6:521–32.
Matza, Louis S., et al. “Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation.Patient Prefer Adherence, vol. 6, 2012, pp. 521–32. Pubmed, doi:10.2147/PPA.S25635.
Matza LS, Phillips GA, Revicki DA, Ascher-Svanum H, Malley KG, Palsgrove AC, Faries DE, Stauffer V, Kinon BJ, Awad AG, Keefe RS, Naber D. Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation. Patient Prefer Adherence. 2012;6:521–532.

Published In

Patient Prefer Adherence

DOI

EISSN

1177-889X

Publication Date

2012

Volume

6

Start / End Page

521 / 532

Location

New Zealand

Related Subject Headings

  • 4203 Health services and systems
  • 1103 Clinical Sciences