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Organic bases of depression in the elderly.

Publication ,  Journal Article
Krishnan, KR
Published in: Annu Rev Med
1991

Early studies suggested that cerebrovascular change may be an etiological factor in the development of late-life depression. With the advent of magnetic resonance imaging (MRI), it has become possible to examine this hypothesis. MRI studies have demonstrated that patients with late-onset depression have more severe and frequent patchy lesions in the frontal deep white matter and basal ganglia than do controls or patients with early-onset depression. Patients with basal ganglia lesions, primarily caudate, are more likely to develop delirium with antidepressants and electroshock treatment (EST). The prognostic significance and the relationship of these lesions to cognitive impairment is unclear.

Duke Scholars

Published In

Annu Rev Med

DOI

ISSN

0066-4219

Publication Date

1991

Volume

42

Start / End Page

261 / 266

Location

United States

Related Subject Headings

  • Magnetic Resonance Imaging
  • Leukoencephalopathy, Progressive Multifocal
  • Humans
  • General & Internal Medicine
  • Depression
  • Brain Diseases
  • Aged
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Krishnan, K. R. (1991). Organic bases of depression in the elderly. Annu Rev Med, 42, 261–266. https://doi.org/10.1146/annurev.me.42.020191.001401
Krishnan, K. R. “Organic bases of depression in the elderly.Annu Rev Med 42 (1991): 261–66. https://doi.org/10.1146/annurev.me.42.020191.001401.
Krishnan KR. Organic bases of depression in the elderly. Annu Rev Med. 1991;42:261–6.
Krishnan, K. R. “Organic bases of depression in the elderly.Annu Rev Med, vol. 42, 1991, pp. 261–66. Pubmed, doi:10.1146/annurev.me.42.020191.001401.
Krishnan KR. Organic bases of depression in the elderly. Annu Rev Med. 1991;42:261–266.

Published In

Annu Rev Med

DOI

ISSN

0066-4219

Publication Date

1991

Volume

42

Start / End Page

261 / 266

Location

United States

Related Subject Headings

  • Magnetic Resonance Imaging
  • Leukoencephalopathy, Progressive Multifocal
  • Humans
  • General & Internal Medicine
  • Depression
  • Brain Diseases
  • Aged
  • 3202 Clinical sciences
  • 1103 Clinical Sciences