Organic bases of depression in the elderly.
Publication
, Journal Article
Krishnan, KR
Published in: Annu Rev Med
1991
Early studies suggested that cerebrovascular change may be an etiological factor in the development of late-life depression. With the advent of magnetic resonance imaging (MRI), it has become possible to examine this hypothesis. MRI studies have demonstrated that patients with late-onset depression have more severe and frequent patchy lesions in the frontal deep white matter and basal ganglia than do controls or patients with early-onset depression. Patients with basal ganglia lesions, primarily caudate, are more likely to develop delirium with antidepressants and electroshock treatment (EST). The prognostic significance and the relationship of these lesions to cognitive impairment is unclear.
Duke Scholars
Published In
Annu Rev Med
DOI
ISSN
0066-4219
Publication Date
1991
Volume
42
Start / End Page
261 / 266
Location
United States
Related Subject Headings
- Magnetic Resonance Imaging
- Leukoencephalopathy, Progressive Multifocal
- Humans
- General & Internal Medicine
- Depression
- Brain Diseases
- Aged
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Krishnan, K. R. (1991). Organic bases of depression in the elderly. Annu Rev Med, 42, 261–266. https://doi.org/10.1146/annurev.me.42.020191.001401
Krishnan, K. R. “Organic bases of depression in the elderly.” Annu Rev Med 42 (1991): 261–66. https://doi.org/10.1146/annurev.me.42.020191.001401.
Krishnan KR. Organic bases of depression in the elderly. Annu Rev Med. 1991;42:261–6.
Krishnan, K. R. “Organic bases of depression in the elderly.” Annu Rev Med, vol. 42, 1991, pp. 261–66. Pubmed, doi:10.1146/annurev.me.42.020191.001401.
Krishnan KR. Organic bases of depression in the elderly. Annu Rev Med. 1991;42:261–266.
Published In
Annu Rev Med
DOI
ISSN
0066-4219
Publication Date
1991
Volume
42
Start / End Page
261 / 266
Location
United States
Related Subject Headings
- Magnetic Resonance Imaging
- Leukoencephalopathy, Progressive Multifocal
- Humans
- General & Internal Medicine
- Depression
- Brain Diseases
- Aged
- 3202 Clinical sciences
- 1103 Clinical Sciences