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Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.

Publication ,  Journal Article
Stanley, M; Rotrosen, J; Sculerati, N; Gershon, S; Kuhn, C; Cohen, BM
Published in: Psychopharmacology (Berl)
1979

The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.

Duke Scholars

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

1979

Volume

66

Issue

1

Start / End Page

23 / 27

Location

Germany

Related Subject Headings

  • Stereotyped Behavior
  • Rats
  • Radioligand Assay
  • Psychiatry
  • Prolactin
  • Male
  • Humans
  • Dopamine Antagonists
  • Chromans
  • Binding, Competitive
 

Citation

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Stanley, M., Rotrosen, J., Sculerati, N., Gershon, S., Kuhn, C., & Cohen, B. M. (1979). Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent. Psychopharmacology (Berl), 66(1), 23–27. https://doi.org/10.1007/BF00431984
Stanley, M., J. Rotrosen, N. Sculerati, S. Gershon, C. Kuhn, and B. M. Cohen. “Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.Psychopharmacology (Berl) 66, no. 1 (1979): 23–27. https://doi.org/10.1007/BF00431984.
Stanley M, Rotrosen J, Sculerati N, Gershon S, Kuhn C, Cohen BM. Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent. Psychopharmacology (Berl). 1979;66(1):23–7.
Stanley, M., et al. “Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.Psychopharmacology (Berl), vol. 66, no. 1, 1979, pp. 23–27. Pubmed, doi:10.1007/BF00431984.
Stanley M, Rotrosen J, Sculerati N, Gershon S, Kuhn C, Cohen BM. Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent. Psychopharmacology (Berl). 1979;66(1):23–27.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

1979

Volume

66

Issue

1

Start / End Page

23 / 27

Location

Germany

Related Subject Headings

  • Stereotyped Behavior
  • Rats
  • Radioligand Assay
  • Psychiatry
  • Prolactin
  • Male
  • Humans
  • Dopamine Antagonists
  • Chromans
  • Binding, Competitive