Experimental dystonia induced by quaternary-chlorpromazine.
Publication
, Journal Article
Rotrosen, J; Stanley, M; Kuhn, C; Wazer, D; Gershon, S
Published in: Neurology
August 1980
When quaternary-chlorpromazine (Q-CPZ) was administered intraventricularly (ICV) to rats, it induced a lateralized dystonic reaction, which progressed to head-to-tail barrel rolling. The syndrome persisted for approximately 10 minutes, was not antagonized by pretreatment with drugs used to treat extrapyramidal movement disorders, and could not be mimicked by ICV administration of dopamine antagonists. Unlike known dopamine antagonists, Q-CPZ does not alter dopamine turnover, cause prolactin release in vivo, or bind to dopamine/neuroleptic receptors in vitro. These data suggest that Q-CPZ differs substantially from CPZ in pharmacologic action, and that it elicits a behavioral syndrome of potential use for studying dystonias.
Duke Scholars
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
August 1980
Volume
30
Issue
8
Start / End Page
878 / 881
Location
United States
Related Subject Headings
- Receptors, Drug
- Rats
- Radioligand Assay
- Prolactin
- Neurology & Neurosurgery
- Male
- Dystonia
- Disease Models, Animal
- Corpus Striatum
- Chlorpromazine
Citation
APA
Chicago
ICMJE
MLA
NLM
Rotrosen, J., Stanley, M., Kuhn, C., Wazer, D., & Gershon, S. (1980). Experimental dystonia induced by quaternary-chlorpromazine. Neurology, 30(8), 878–881. https://doi.org/10.1212/wnl.30.8.878
Rotrosen, J., M. Stanley, C. Kuhn, D. Wazer, and S. Gershon. “Experimental dystonia induced by quaternary-chlorpromazine.” Neurology 30, no. 8 (August 1980): 878–81. https://doi.org/10.1212/wnl.30.8.878.
Rotrosen J, Stanley M, Kuhn C, Wazer D, Gershon S. Experimental dystonia induced by quaternary-chlorpromazine. Neurology. 1980 Aug;30(8):878–81.
Rotrosen, J., et al. “Experimental dystonia induced by quaternary-chlorpromazine.” Neurology, vol. 30, no. 8, Aug. 1980, pp. 878–81. Pubmed, doi:10.1212/wnl.30.8.878.
Rotrosen J, Stanley M, Kuhn C, Wazer D, Gershon S. Experimental dystonia induced by quaternary-chlorpromazine. Neurology. 1980 Aug;30(8):878–881.
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
August 1980
Volume
30
Issue
8
Start / End Page
878 / 881
Location
United States
Related Subject Headings
- Receptors, Drug
- Rats
- Radioligand Assay
- Prolactin
- Neurology & Neurosurgery
- Male
- Dystonia
- Disease Models, Animal
- Corpus Striatum
- Chlorpromazine