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Lack of potency of metoclopramide's metabolites in various dopaminergic models.

Publication ,  Journal Article
Stanley, M; Wazer, D; Virgilio, J; Kuhn, CM; Benson, DI; Meyerson, LR
Published in: Pharmacol Biochem Behav
February 1983

The dopaminergic properties of metoclopramide and four of its metabolites were determined in a series of in vivo and in vitro tests. In vivo measures included changes in dopamine turnover, serum prolactin levels and antagonism of apomorphine-induced stereotyped behavior. In each of these tests the four metabolites were either completely inactive or significantly less potent than the parent compound. The potency of metoclopramide and its metabolites in in vitro dopamine/neuroleptic receptor models was compared to the potency of standard reference compounds. In vitro results indicate that none of the four metabolites tested had antagonist activity in any of the receptor models in which they were evaluated. These findings will be discussed in light of the current understanding of receptor models as they relate to antipsychotic efficacy.

Duke Scholars

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

February 1983

Volume

18

Issue

2

Start / End Page

263 / 266

Location

United States

Related Subject Headings

  • Tetrahydronaphthalenes
  • Stereotyped Behavior
  • Spiperone
  • Rats, Inbred Strains
  • Rats
  • Prolactin
  • Neurology & Neurosurgery
  • Metoclopramide
  • Male
  • Humans
 

Citation

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Stanley, M., Wazer, D., Virgilio, J., Kuhn, C. M., Benson, D. I., & Meyerson, L. R. (1983). Lack of potency of metoclopramide's metabolites in various dopaminergic models. Pharmacol Biochem Behav, 18(2), 263–266. https://doi.org/10.1016/0091-3057(83)90372-6
Stanley, M., D. Wazer, J. Virgilio, C. M. Kuhn, D. I. Benson, and L. R. Meyerson. “Lack of potency of metoclopramide's metabolites in various dopaminergic models.Pharmacol Biochem Behav 18, no. 2 (February 1983): 263–66. https://doi.org/10.1016/0091-3057(83)90372-6.
Stanley M, Wazer D, Virgilio J, Kuhn CM, Benson DI, Meyerson LR. Lack of potency of metoclopramide's metabolites in various dopaminergic models. Pharmacol Biochem Behav. 1983 Feb;18(2):263–6.
Stanley, M., et al. “Lack of potency of metoclopramide's metabolites in various dopaminergic models.Pharmacol Biochem Behav, vol. 18, no. 2, Feb. 1983, pp. 263–66. Pubmed, doi:10.1016/0091-3057(83)90372-6.
Stanley M, Wazer D, Virgilio J, Kuhn CM, Benson DI, Meyerson LR. Lack of potency of metoclopramide's metabolites in various dopaminergic models. Pharmacol Biochem Behav. 1983 Feb;18(2):263–266.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

February 1983

Volume

18

Issue

2

Start / End Page

263 / 266

Location

United States

Related Subject Headings

  • Tetrahydronaphthalenes
  • Stereotyped Behavior
  • Spiperone
  • Rats, Inbred Strains
  • Rats
  • Prolactin
  • Neurology & Neurosurgery
  • Metoclopramide
  • Male
  • Humans