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Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth.

Publication ,  Journal Article
Bartolome, JV; Bartolome, MB; Daltner, LA; Evans, CJ; Barchas, JD; Kuhn, CM; Schanberg, SM
Published in: Life Sci
June 23, 1986

Ornithine decarboxlyase (ODC) catalyzes the initial step in the bio-synthesis of the polyamines spermidine and spermine, which are key regulators of cell growth, proliferation and differentiation. Intracisternal administration of beta-endorphin (1 microgram) to 6 day-old rats markedly decreased brain, liver, heart and kidney ODC activity. Conversely, subcutaneous administration of beta-endorphin increased ODC activity in the heart and liver. Thus, ODC inhibition in peripheral organs in rat pups given beta-endorphin intracisternally appears to reflect central effects of this neuropeptide. Experiments were also carried out to test whether opioid receptors are involved in these tissue ODC responses. Naloxone prevented the decreases in brain ODC indicating the participation of opioid receptors in that process. In contrast, naloxone did not alter ODC responses in peripheral organs in rat pups given beta-endorphin intracisternally, indicating that these effects are independent of its classical opioid character. These results support the view that endogenous beta-endorphin may play an important role in organogenesis by modulating the growth-related enzyme ODC. The data also suggest that the regulation of peripheral organ development by beta-endorphin may be mediated through the release of growth regulatory substances from the CNS.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

June 23, 1986

Volume

38

Issue

25

Start / End Page

2355 / 2362

Location

Netherlands

Related Subject Headings

  • beta-Endorphin
  • Spermine
  • Spermidine
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Pharmacology & Pharmacy
  • Ornithine Decarboxylase
  • Naloxone
  • Male
 

Citation

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Bartolome, J. V., Bartolome, M. B., Daltner, L. A., Evans, C. J., Barchas, J. D., Kuhn, C. M., & Schanberg, S. M. (1986). Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth. Life Sci, 38(25), 2355–2362. https://doi.org/10.1016/0024-3205(86)90643-0
Bartolome, J. V., M. B. Bartolome, L. A. Daltner, C. J. Evans, J. D. Barchas, C. M. Kuhn, and S. M. Schanberg. “Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth.Life Sci 38, no. 25 (June 23, 1986): 2355–62. https://doi.org/10.1016/0024-3205(86)90643-0.
Bartolome JV, Bartolome MB, Daltner LA, Evans CJ, Barchas JD, Kuhn CM, et al. Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth. Life Sci. 1986 Jun 23;38(25):2355–62.
Bartolome, J. V., et al. “Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth.Life Sci, vol. 38, no. 25, June 1986, pp. 2355–62. Pubmed, doi:10.1016/0024-3205(86)90643-0.
Bartolome JV, Bartolome MB, Daltner LA, Evans CJ, Barchas JD, Kuhn CM, Schanberg SM. Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth. Life Sci. 1986 Jun 23;38(25):2355–2362.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

June 23, 1986

Volume

38

Issue

25

Start / End Page

2355 / 2362

Location

Netherlands

Related Subject Headings

  • beta-Endorphin
  • Spermine
  • Spermidine
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Pharmacology & Pharmacy
  • Ornithine Decarboxylase
  • Naloxone
  • Male