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SU-E-T-626: Individualized Trade-Off of Dose Coverage and Sparing in IMRT Planning.

Publication ,  Conference
Yuan, L; Ge, Y; Li, T; Yin, F; Wu, QJ
Published in: Med Phys
June 2012

PURPOSE: We present an evidence-based approach to quantifying the dose sparing trade-offs between different Organs-at-risk (OARs) and the trade-off between OAR dose sparing and target dose coverage in IMRT plans. METHODS: The interaction between dose sparing of different OARs and between target dose coverage and OAR dose sparing are modeled using high-quality prior IMRT plans of prostate, head-and-neck (HN), and spine SBRT cases. The dose sparing for each OAR is modeled separately at first based on their own anatomical features and then the contributions from other OARs or PTV are added into the model to account for the possible trade-off effects in plans whose modeled OAR DVH deviates from that of actual plans. RESULTS: The most significant OAR dose sparing trade-off is between bladder and rectum in prostate plans and between the left and the right parotids in HN plans. Trade-off is most apparent when the parotid on one side has very large overlap with the PTV. In most of these plans (83%), the planer chooses to loosen the dose constraint for that parotid in exchange for lower contra-lateral parotid median dose. The interaction between OAR dose sparing and PTV dose coverage is most significant in spine SBRT plans, (R2=0.37). Another important factor is the tightness of the geometric enclosure of PTV around OAR (R2=0.38). CONCLUSIONS: The dosimetric trade-off between multiple OARs and between PTV and OAR in IMRT planning is quantified by studying prior plans. These findings will help physicians and planners obtain better OAR dose sparing by exploring different trade-off options for individual patient cases. Partially supported by a master research agreement with Varian Medical Systems, Inc.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2012

Volume

39

Issue

6Part20

Start / End Page

3850

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yuan, L., Ge, Y., Li, T., Yin, F., & Wu, Q. J. (2012). SU-E-T-626: Individualized Trade-Off of Dose Coverage and Sparing in IMRT Planning. In Med Phys (Vol. 39, p. 3850). United States. https://doi.org/10.1118/1.4735716
Yuan, L., Y. Ge, T. Li, F. Yin, and Q Jackie Wu. “SU-E-T-626: Individualized Trade-Off of Dose Coverage and Sparing in IMRT Planning.” In Med Phys, 39:3850, 2012. https://doi.org/10.1118/1.4735716.
Yuan L, Ge Y, Li T, Yin F, Wu QJ. SU-E-T-626: Individualized Trade-Off of Dose Coverage and Sparing in IMRT Planning. In: Med Phys. 2012. p. 3850.
Yuan, L., et al. “SU-E-T-626: Individualized Trade-Off of Dose Coverage and Sparing in IMRT Planning.Med Phys, vol. 39, no. 6Part20, 2012, p. 3850. Pubmed, doi:10.1118/1.4735716.
Yuan L, Ge Y, Li T, Yin F, Wu QJ. SU-E-T-626: Individualized Trade-Off of Dose Coverage and Sparing in IMRT Planning. Med Phys. 2012. p. 3850.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2012

Volume

39

Issue

6Part20

Start / End Page

3850

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences