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Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol.

Publication ,  Journal Article
Zipursky, RB; Gu, H; Green, AI; Perkins, DO; Tohen, MF; McEvoy, JP; Strakowski, SM; Sharma, T; Kahn, RS; Gur, RE; Tollefson, GD; Lieberman, JA
Published in: Br J Psychiatry
December 2005

BACKGROUND: Substantial weight gain is common with many atypical antipsychotics. AIMS: To evaluate the extent, time course and predictors of weight gain and its effect on study retention among people with first-episode psychosis treated with olanzapine or haloperidol. METHOD: Survival analysis assessed time to potentially clinically significant weight gain (> or =7%) and the effect of weight gain on study retention. Weight gain during the 2-year study was summarised using last-observation-carried-forward (LOCF), observed cases and study completion approaches. RESULTS: After 2 years of treatment, LOCF mean weight gain was 10.2 kg (s.d.=10.1) for olanzapine (n=131) and 4.0 kg (s.d.=7.3) for haloperidol (n=132); observed cases mean weight gain was 15.4 kg (s.d.=10.0) for olanzapine and 7.5 kg (s.d.=9.2) for haloperidol. Change in body mass index was significantly predicted only by treatment group (P < 0.0001). CONCLUSIONS: Olanzapine was associated with significantly greater weight gain than haloperidol, with both leading to greater weight gain than previously described.

Duke Scholars

Published In

Br J Psychiatry

DOI

ISSN

0007-1250

Publication Date

December 2005

Volume

187

Start / End Page

537 / 543

Location

England

Related Subject Headings

  • Weight Gain
  • Treatment Outcome
  • Time Factors
  • Schizophrenia
  • Psychiatry
  • Patient Dropouts
  • Olanzapine
  • Male
  • Humans
  • Haloperidol
 

Citation

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Zipursky, R. B., Gu, H., Green, A. I., Perkins, D. O., Tohen, M. F., McEvoy, J. P., … Lieberman, J. A. (2005). Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol. Br J Psychiatry, 187, 537–543. https://doi.org/10.1192/bjp.187.6.537
Zipursky, Robert B., Hongbin Gu, Alan I. Green, Diana O. Perkins, Mauricio F. Tohen, Joseph P. McEvoy, Stephen M. Strakowski, et al. “Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol.Br J Psychiatry 187 (December 2005): 537–43. https://doi.org/10.1192/bjp.187.6.537.
Zipursky RB, Gu H, Green AI, Perkins DO, Tohen MF, McEvoy JP, et al. Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol. Br J Psychiatry. 2005 Dec;187:537–43.
Zipursky, Robert B., et al. “Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol.Br J Psychiatry, vol. 187, Dec. 2005, pp. 537–43. Pubmed, doi:10.1192/bjp.187.6.537.
Zipursky RB, Gu H, Green AI, Perkins DO, Tohen MF, McEvoy JP, Strakowski SM, Sharma T, Kahn RS, Gur RE, Tollefson GD, Lieberman JA. Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol. Br J Psychiatry. 2005 Dec;187:537–543.
Journal cover image

Published In

Br J Psychiatry

DOI

ISSN

0007-1250

Publication Date

December 2005

Volume

187

Start / End Page

537 / 543

Location

England

Related Subject Headings

  • Weight Gain
  • Treatment Outcome
  • Time Factors
  • Schizophrenia
  • Psychiatry
  • Patient Dropouts
  • Olanzapine
  • Male
  • Humans
  • Haloperidol