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Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse

Publication ,  Journal Article
Graham, SD; Poulton, SH; Woodard, BH; Lyles, KW; Paulson, DF; Linder, J
Published in: The Prostate
January 1, 1985

There are few established human prostatic adenocarcinoma cell lines in existence. Most established lines are nonfunctional and hormonally insensitive. A human prostate adenocarcinoma (9479) has been serially transplanted for more than 4 years in athymic nude mice. The tumor is estrogen and androgen insensitive, is transplantable between mice with a high rate of success. The tumor does not produce enzymatically measurable acid phosphatase, but does produce immunologically identifiable acid phosphatase. Not only has the tumor retained its original morphology, it also appears to produce a factor producing hypophosphatemia. Current studies in regards to the endocrinological aspects of this tumor are in progress. We propose that acid phosphatase is produced, but in an altered form. Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company

Duke Scholars

Published In

The Prostate

DOI

EISSN

1097-0045

ISSN

0270-4137

Publication Date

January 1, 1985

Volume

7

Issue

4

Start / End Page

369 / 376

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Graham, S. D., Poulton, S. H., Woodard, B. H., Lyles, K. W., Paulson, D. F., & Linder, J. (1985). Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse. The Prostate, 7(4), 369–376. https://doi.org/10.1002/pros.2990070405
Graham, S. D., S. H. Poulton, B. H. Woodard, K. W. Lyles, D. F. Paulson, and J. Linder. “Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse.” The Prostate 7, no. 4 (January 1, 1985): 369–76. https://doi.org/10.1002/pros.2990070405.
Graham SD, Poulton SH, Woodard BH, Lyles KW, Paulson DF, Linder J. Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse. The Prostate. 1985 Jan 1;7(4):369–76.
Graham, S. D., et al. “Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse.” The Prostate, vol. 7, no. 4, Jan. 1985, pp. 369–76. Scopus, doi:10.1002/pros.2990070405.
Graham SD, Poulton SH, Woodard BH, Lyles KW, Paulson DF, Linder J. Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse. The Prostate. 1985 Jan 1;7(4):369–376.
Journal cover image

Published In

The Prostate

DOI

EISSN

1097-0045

ISSN

0270-4137

Publication Date

January 1, 1985

Volume

7

Issue

4

Start / End Page

369 / 376

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences