A study of cancer cell metastasis using microfluidic transmigration device
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Fu, Y; Vandongen, AMJ; Bourouina, T; Park, WT; Je, MY; Tsai, JM; Kwong, DL; Liu, AQ
Published in: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
May 7, 2012
Metastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resolution imaging. Results showed that the deformation of cell nucleus is critical for the transmigration of breast cancer cell MDA-MB-231. Condensation of chromatin by drug plicamycinon significantly impaired their deformation abilities and subsequently reduced the transmigration by 2 to 3 fold for microchannel smaller than 10 μm x 5 μm. As transmigration is critical for cancer metastasis, the results will be useful in designing new anti-cancer therapy. © 2012 IEEE.
Duke Scholars
Published In
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
DOI
ISSN
1084-6999
ISBN
9781467303248
Publication Date
May 7, 2012
Start / End Page
773 / 776
Citation
APA
Chicago
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MLA
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Fu, Y., Vandongen, A. M. J., Bourouina, T., Park, W. T., Je, M. Y., Tsai, J. M., … Liu, A. Q. (2012). A study of cancer cell metastasis using microfluidic transmigration device. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 773–776). https://doi.org/10.1109/MEMSYS.2012.6170300
Fu, Y., A. M. J. Vandongen, T. Bourouina, W. T. Park, M. Y. Je, J. M. Tsai, D. L. Kwong, and A. Q. Liu. “A study of cancer cell metastasis using microfluidic transmigration device.” In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 773–76, 2012. https://doi.org/10.1109/MEMSYS.2012.6170300.
Fu Y, Vandongen AMJ, Bourouina T, Park WT, Je MY, Tsai JM, et al. A study of cancer cell metastasis using microfluidic transmigration device. In: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2012. p. 773–6.
Fu, Y., et al. “A study of cancer cell metastasis using microfluidic transmigration device.” Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 2012, pp. 773–76. Scopus, doi:10.1109/MEMSYS.2012.6170300.
Fu Y, Vandongen AMJ, Bourouina T, Park WT, Je MY, Tsai JM, Kwong DL, Liu AQ. A study of cancer cell metastasis using microfluidic transmigration device. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2012. p. 773–776.
Published In
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
DOI
ISSN
1084-6999
ISBN
9781467303248
Publication Date
May 7, 2012
Start / End Page
773 / 776