The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis.
Publication
, Journal Article
Machado, MV; Yang, Y; Diehl, AM
Published in: J Clin Invest
January 2013
In response to feeding, insulin promotes the uptake of sugar in peripheral tissues and suppresses the production of sugar, a process called gluconeogenesis, in the liver. Recent research has shown that chronic inflammation promotes insulin resistance, and in turn, chronically high glucose levels can drive inflammation. In this issue of the JCI, Stanya et al. investigate the connection between inflammation and glucose homeostasis by analyzing the effect of the antiinflammatory cytokine IL-13. Their results suggest that IL-13 plays an unexpected role in the regulation of glucose homeostasis by modulating gluconeogenesis and may be a useful therapeutic target for treatment of diabetes and metabolic syndrome.
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Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
January 2013
Volume
123
Issue
1
Start / End Page
115 / 117
Location
United States
Related Subject Headings
- Liver
- Interleukin-13
- Immunology
- Glucose
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
Citation
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Chicago
ICMJE
MLA
NLM
Machado, M. V., Yang, Y., & Diehl, A. M. (2013). The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis. J Clin Invest, 123(1), 115–117. https://doi.org/10.1172/JCI67238
Machado, Mariana Verdelho, Yiping Yang, and Anna Mae Diehl. “The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis.” J Clin Invest 123, no. 1 (January 2013): 115–17. https://doi.org/10.1172/JCI67238.
Machado MV, Yang Y, Diehl AM. The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis. J Clin Invest. 2013 Jan;123(1):115–7.
Machado, Mariana Verdelho, et al. “The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis.” J Clin Invest, vol. 123, no. 1, Jan. 2013, pp. 115–17. Pubmed, doi:10.1172/JCI67238.
Machado MV, Yang Y, Diehl AM. The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis. J Clin Invest. 2013 Jan;123(1):115–117.
Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
January 2013
Volume
123
Issue
1
Start / End Page
115 / 117
Location
United States
Related Subject Headings
- Liver
- Interleukin-13
- Immunology
- Glucose
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences