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SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome.

Publication ,  Journal Article
Green, MF; Hirschey, MD
Published in: J Gerontol A Biol Sci Med Sci
February 2013

Eating a "Western diet" high in fat and sugars is associated with accelerated development of age-related metabolic diseases such as obesity, insulin resistance, and diabetes while incidences of these diseases are decreased on a low-calorie diet. The mitochondrial NAD(+)-dependent protein deacetylase SIRT3 has previously been shown to be important in adapting to metabolic stress brought on by fasting and calorie restriction. During times of metabolic stress, SIRT3 is upregulated and maintains homeostasis following nutrient deprivation by turning on pathways such as fatty acid oxidation, antioxidant production, and the urea cycle. New studies now demonstrate that SIRT3 is regulated during nutrient excess. During high-fat diet feeding, SIRT3 is downregulated leading to mitochondrial protein hyperacetylation. The consequence of this hyperacetylation is the accelerated development of metabolic syndrome. Thus, SIRT3 is emerging as an important metabolic sensor working to restore metabolic homeostasis during times of stress.

Duke Scholars

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

February 2013

Volume

68

Issue

2

Start / End Page

105 / 107

Location

United States

Related Subject Headings

  • Sirtuin 3
  • Signal Transduction
  • Reactive Oxygen Species
  • Muscle, Skeletal
  • Mitochondrial Proteins
  • Mitochondria
  • Metabolic Syndrome
  • Insulin Resistance
  • Humans
  • Gerontology
 

Citation

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Green, M. F., & Hirschey, M. D. (2013). SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome. J Gerontol A Biol Sci Med Sci, 68(2), 105–107. https://doi.org/10.1093/gerona/gls132
Green, Michelle F., and Matthew D. Hirschey. “SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome.J Gerontol A Biol Sci Med Sci 68, no. 2 (February 2013): 105–7. https://doi.org/10.1093/gerona/gls132.
Green MF, Hirschey MD. SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome. J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):105–7.
Green, Michelle F., and Matthew D. Hirschey. “SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome.J Gerontol A Biol Sci Med Sci, vol. 68, no. 2, Feb. 2013, pp. 105–07. Pubmed, doi:10.1093/gerona/gls132.
Green MF, Hirschey MD. SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome. J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):105–107.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

February 2013

Volume

68

Issue

2

Start / End Page

105 / 107

Location

United States

Related Subject Headings

  • Sirtuin 3
  • Signal Transduction
  • Reactive Oxygen Species
  • Muscle, Skeletal
  • Mitochondrial Proteins
  • Mitochondria
  • Metabolic Syndrome
  • Insulin Resistance
  • Humans
  • Gerontology