Skip to main content

Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial.

Publication ,  Journal Article
Hung, EW; Mayes, MD; Sharif, R; Assassi, S; Machicao, VI; Hosing, C; St Clair, EW; Furst, DE; Khanna, D; Forman, S; Mineishi, S; Phillips, K ...
Published in: J Rheumatol
April 2013

OBJECTIVE: To describe the prevalence and clinical correlates of endoscopic gastric antral vascular ectasia (GAVE; "watermelon stomach") in early diffuse systemic sclerosis (SSc). METHODS: Subjects with early, diffuse SSc and evidence of specific internal organ involvement were considered for the Scleroderma: Cyclophosphamide Or Transplant (SCOT) trial. In the screening procedures, all patients underwent upper gastrointestinal endoscopy. Patients were then categorized into those with or without endoscopic evidence of GAVE. Demographic data, clinical disease characteristics, and autoantibody data were compared using Pearson chi-square or Student t tests. RESULTS: Twenty-three of 103 (22.3%) individuals were found to have GAVE on endoscopy. Although not statistically significant, anti-topoisomerase I (anti-Scl70) was detected less frequently among those with GAVE (18.8% vs 44.7%; p = 0.071). Similarly, anti-RNP antibodies (anti-U1 RNP) showed a trend to a negative association with GAVE (0 vs 18.4%; p = 0.066). There was no association between anti-RNA polymerase III and GAVE. Patients with GAVE had significantly more erythema or vascular ectasias in other parts of the stomach (26.1% vs 5.0%; p = 0.003). CONCLUSION: Endoscopic GAVE was present on screening in almost one-fourth of these highly selected patients with early and severe diffuse SSc. While anti-Scl70 and anti-U1 RNP trended toward a negative association with GAVE, there was no correlation between anti-RNA Pol III and GAVE. Patients with GAVE had a higher frequency of other gastric vascular ectasias outside the antrum, suggesting that GAVE may represent part of the spectrum of the vasculopathy in SSc.

Duke Scholars

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

April 2013

Volume

40

Issue

4

Start / End Page

455 / 460

Location

Canada

Related Subject Headings

  • Scleroderma, Diffuse
  • Middle Aged
  • Male
  • Humans
  • Gastroscopy
  • Gastric Antral Vascular Ectasia
  • Female
  • Arthritis & Rheumatology
  • Aged
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hung, E. W., Mayes, M. D., Sharif, R., Assassi, S., Machicao, V. I., Hosing, C., … Sullivan, K. M. (2013). Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial. J Rheumatol, 40(4), 455–460. https://doi.org/10.3899/jrheum.121087
Hung, Emily W., Maureen D. Mayes, Roozbeh Sharif, Shervin Assassi, Victor I. Machicao, Chitra Hosing, E William St Clair, et al. “Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial.J Rheumatol 40, no. 4 (April 2013): 455–60. https://doi.org/10.3899/jrheum.121087.
Hung EW, Mayes MD, Sharif R, Assassi S, Machicao VI, Hosing C, et al. Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial. J Rheumatol. 2013 Apr;40(4):455–60.
Hung, Emily W., et al. “Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial.J Rheumatol, vol. 40, no. 4, Apr. 2013, pp. 455–60. Pubmed, doi:10.3899/jrheum.121087.
Hung EW, Mayes MD, Sharif R, Assassi S, Machicao VI, Hosing C, St Clair EW, Furst DE, Khanna D, Forman S, Mineishi S, Phillips K, Seibold JR, Bredeson C, Csuka ME, Nash RA, Wener MH, Simms R, Ballen K, Leclercq S, Storek J, Goldmuntz E, Welch B, Keyes-Elstein L, Castina S, Crofford LJ, Mcsweeney P, Sullivan KM. Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial. J Rheumatol. 2013 Apr;40(4):455–460.

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

April 2013

Volume

40

Issue

4

Start / End Page

455 / 460

Location

Canada

Related Subject Headings

  • Scleroderma, Diffuse
  • Middle Aged
  • Male
  • Humans
  • Gastroscopy
  • Gastric Antral Vascular Ectasia
  • Female
  • Arthritis & Rheumatology
  • Aged
  • Adult