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Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial.

Publication ,  Journal Article
McMurray, JJV; Ezekowitz, JA; Lewis, BS; Gersh, BJ; van Diepen, S; Amerena, J; Bartunek, J; Commerford, P; Oh, B-H; Harjola, V-P; Al-Khatib, SM ...
Published in: Circ Heart Fail
May 2013

BACKGROUND: We examined the risk of stroke or systemic embolism (SSE) conferred by heart failure (HF) and left ventricular systolic dysfunction (LVSD) in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation Trial (ARISTOTLE), as well as the effect of apixaban versus warfarin. METHODS AND RESULTS: The risk of a number of outcomes, including the composite of SSE or death (to take account of competing risks) and composite of SSE, major bleeding, or death (net clinical benefit) were calculated in 3 patient groups: (1) no HF/no LVSD (n=8728), (2) HF/no LVSD (n=3207), and (3) LVSD with/without symptomatic HF (n=2736). The rate of both outcomes was highest in patients with LVSD (SSE or death 8.06; SSE, major bleeding, or death 10.46 per 100 patient-years), intermediate for HF but preserved LV systolic function (5.32; 7.24), and lowest in patients without HF or LVSD (1.54; 5.27); each comparison P<0.0001. Each outcome was less frequent in patients treated with apixaban: in all ARISTOTLE patients, the apixaban/warfarin hazard ratio for SSE or death was 0.89 (95% confidence interval, 0.81-0.98; P=0.02); for SSE, major bleed, or death it was 0.85 (0.78-0.92; P<0.001). There was no heterogeneity of treatment effect across the 3 groups. CONCLUSIONS: Patients with LVSD (with/without HF) had a higher risk of SSE or death (but similar rate of SSE) compared with patients with HF but preserved LV systolic function; both had a greater risk than patients without either HF or LVSD. Apixaban reduced the risk of both outcomes more than warfarin in all 3 patient groups. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00412984.

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Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

May 2013

Volume

6

Issue

3

Start / End Page

451 / 460

Location

United States

Related Subject Headings

  • Warfarin
  • Ventricular Dysfunction, Left
  • Stroke
  • Risk Assessment
  • Retrospective Studies
  • Pyridones
  • Pyrazoles
  • Middle Aged
  • Male
  • Humans
 

Citation

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McMurray, J. J. V., Ezekowitz, J. A., Lewis, B. S., Gersh, B. J., van Diepen, S., Amerena, J., … ARISTOTLE Committees and Investigators, . (2013). Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial. Circ Heart Fail, 6(3), 451–460. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000143
McMurray, John J. V., Justin A. Ezekowitz, Basil S. Lewis, Bernard J. Gersh, Sean van Diepen, John Amerena, Jozef Bartunek, et al. “Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial.Circ Heart Fail 6, no. 3 (May 2013): 451–60. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000143.
McMurray JJV, Ezekowitz JA, Lewis BS, Gersh BJ, van Diepen S, Amerena J, et al. Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial. Circ Heart Fail. 2013 May;6(3):451–60.
McMurray, John J. V., et al. “Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial.Circ Heart Fail, vol. 6, no. 3, May 2013, pp. 451–60. Pubmed, doi:10.1161/CIRCHEARTFAILURE.112.000143.
McMurray JJV, Ezekowitz JA, Lewis BS, Gersh BJ, van Diepen S, Amerena J, Bartunek J, Commerford P, Oh B-H, Harjola V-P, Al-Khatib SM, Hanna M, Alexander JH, Lopes RD, Wojdyla DM, Wallentin L, Granger CB, ARISTOTLE Committees and Investigators. Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial. Circ Heart Fail. 2013 May;6(3):451–460.

Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

May 2013

Volume

6

Issue

3

Start / End Page

451 / 460

Location

United States

Related Subject Headings

  • Warfarin
  • Ventricular Dysfunction, Left
  • Stroke
  • Risk Assessment
  • Retrospective Studies
  • Pyridones
  • Pyrazoles
  • Middle Aged
  • Male
  • Humans