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Social environment influences the relationship between genotype and gene expression in wild baboons.

Publication ,  Journal Article
Runcie, DE; Wiedmann, RT; Archie, EA; Altmann, J; Wray, GA; Alberts, SC; Tung, J
Published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
May 2013

Variation in the social environment can have profound effects on survival and reproduction in wild social mammals. However, we know little about the degree to which these effects are influenced by genetic differences among individuals, and conversely, the degree to which social environmental variation mediates genetic reaction norms. To better understand these relationships, we investigated the potential for dominance rank, social connectedness and group size to modify the effects of genetic variation on gene expression in the wild baboons of the Amboseli basin. We found evidence for a number of gene-environment interactions (GEIs) associated with variation in the social environment, encompassing social environments experienced in adulthood as well as persistent effects of early life social environment. Social connectedness, maternal dominance rank and group size all interacted with genotype to influence gene expression in at least one sex, and either in early life or in adulthood. These results suggest that social and behavioural variation, akin to other factors such as age and sex, can impact the genotype-phenotype relationship. We conclude that GEIs mediated by the social environment are important in the evolution and maintenance of individual differences in wild social mammals, including individual differences in responses to social stressors.

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Published In

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

DOI

EISSN

1471-2970

ISSN

0962-8436

Publication Date

May 2013

Volume

368

Issue

1618

Start / End Page

20120345

Related Subject Headings

  • Social Environment
  • Social Dominance
  • Sex Factors
  • Regulatory Sequences, Nucleic Acid
  • Polymorphism, Single Nucleotide
  • Papio
  • Male
  • Genotype
  • Gene-Environment Interaction
  • Gene Expression
 

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Runcie, D. E., Wiedmann, R. T., Archie, E. A., Altmann, J., Wray, G. A., Alberts, S. C., & Tung, J. (2013). Social environment influences the relationship between genotype and gene expression in wild baboons. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 368(1618), 20120345. https://doi.org/10.1098/rstb.2012.0345
Runcie, Daniel E., Ralph T. Wiedmann, Elizabeth A. Archie, Jeanne Altmann, Gregory A. Wray, Susan C. Alberts, and Jenny Tung. “Social environment influences the relationship between genotype and gene expression in wild baboons.Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 368, no. 1618 (May 2013): 20120345. https://doi.org/10.1098/rstb.2012.0345.
Runcie DE, Wiedmann RT, Archie EA, Altmann J, Wray GA, Alberts SC, et al. Social environment influences the relationship between genotype and gene expression in wild baboons. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2013 May;368(1618):20120345.
Runcie, Daniel E., et al. “Social environment influences the relationship between genotype and gene expression in wild baboons.Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 368, no. 1618, May 2013, p. 20120345. Epmc, doi:10.1098/rstb.2012.0345.
Runcie DE, Wiedmann RT, Archie EA, Altmann J, Wray GA, Alberts SC, Tung J. Social environment influences the relationship between genotype and gene expression in wild baboons. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2013 May;368(1618):20120345.
Journal cover image

Published In

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

DOI

EISSN

1471-2970

ISSN

0962-8436

Publication Date

May 2013

Volume

368

Issue

1618

Start / End Page

20120345

Related Subject Headings

  • Social Environment
  • Social Dominance
  • Sex Factors
  • Regulatory Sequences, Nucleic Acid
  • Polymorphism, Single Nucleotide
  • Papio
  • Male
  • Genotype
  • Gene-Environment Interaction
  • Gene Expression