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Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.

Publication ,  Journal Article
Azrad, M; Vollmer, RT; Madden, J; Dewhirst, M; Polascik, TJ; Snyder, DC; Ruffin, MT; Moul, JW; Brenner, DE; Demark-Wahnefried, W
Published in: J Med Food
April 2013

Enterolactone and enterodiol, mammalian lignans derived from dietary sources such as flaxseed, sesame seeds, kale, broccoli, and apricots, may impede tumor proliferation by inhibiting activation of nuclear factor kappa B (NFκB) and vascular endothelial growth factor (VEGF). We examined the associations between urinary enterolactone and enterodiol with prostatic tumor expression of NFκB, VEGF, and Ki67 among 147 patients with prostate cancer who participated in a presurgical trial of flaxseed supplementation (30 g/day) for ~30 days. Urinary enterolignans and tissue biomarkers were determined by high-performance liquid chromatography and immunohistochemistry, respectively. After supplementation, we observed significant correlations between intakes of plant lignan and urinary concentrations of total enterolignans (ρ=0.677, P<.0001), enterolactone (ρ=0.676, P<.0001), and enterodiol (ρ=0.628, P<.0001). Importantly, we observed that total urinary enterolignans and enterolactone were significantly and inversely correlated with Ki67 in the tumor tissue (ρ=-0.217, P=.011, and ρ=-0.230, P=.007, respectively), and a near-significant inverse association was observed for enterodiol (ρ=-0.159, P=.064). An inverse association was observed between enterolactone and VEGF (ρ=-0.143, P=.141), although this did not reach statistical significance. We did not observe an association between enterolignans and NFκB. In conclusion, flaxseed-derived enterolignans may hinder cancer cell proliferation via VEGF-associated pathways.

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Published In

J Med Food

DOI

EISSN

1557-7600

Publication Date

April 2013

Volume

16

Issue

4

Start / End Page

357 / 360

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Prostatic Neoplasms
  • Plant Extracts
  • Phytotherapy
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Lignans
  • Ki-67 Antigen
  • Humans
 

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Azrad, M., Vollmer, R. T., Madden, J., Dewhirst, M., Polascik, T. J., Snyder, D. C., … Demark-Wahnefried, W. (2013). Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. J Med Food, 16(4), 357–360. https://doi.org/10.1089/jmf.2012.0159
Azrad, Maria, Robin T. Vollmer, John Madden, Mark Dewhirst, Thomas J. Polascik, Denise C. Snyder, Mack T. Ruffin, Judd W. Moul, Dean E. Brenner, and Wendy Demark-Wahnefried. “Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.J Med Food 16, no. 4 (April 2013): 357–60. https://doi.org/10.1089/jmf.2012.0159.
Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, et al. Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. J Med Food. 2013 Apr;16(4):357–60.
Azrad, Maria, et al. “Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.J Med Food, vol. 16, no. 4, Apr. 2013, pp. 357–60. Pubmed, doi:10.1089/jmf.2012.0159.
Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W. Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. J Med Food. 2013 Apr;16(4):357–360.
Journal cover image

Published In

J Med Food

DOI

EISSN

1557-7600

Publication Date

April 2013

Volume

16

Issue

4

Start / End Page

357 / 360

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Prostatic Neoplasms
  • Plant Extracts
  • Phytotherapy
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Lignans
  • Ki-67 Antigen
  • Humans