Skip to main content

Innate immunity and its regulation by mast cells.

Publication ,  Journal Article
St John, AL; Abraham, SN
Published in: J Immunol
May 1, 2013

Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage, constitute a major sensory arm of the innate immune system. In this review we discuss the evidence supporting the dual role of MCs, both as sentinels for invading pathogens and as regulatory cells throughout the course of acute inflammation, from its initiation to resolution. This versatility is dependent on the ability of MCs to detect pathogens and danger signals and release a unique panel of mediators to promote pathogen-specific clearance mechanisms, such as through cellular recruitment or vascular permeability. It is increasingly understood that MCs also contribute to the regulated contraction of immune activation that occurs within tissues as inflammation resolves. This overarching regulatory control over innate immune processes has made MCs successful targets to purposefully enhance or, alternatively, suppress MC responses in multiple therapeutic contexts.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

May 1, 2013

Volume

190

Issue

9

Start / End Page

4458 / 4463

Location

United States

Related Subject Headings

  • Mast Cells
  • Inflammation
  • Immunology
  • Immunity, Innate
  • Humans
  • Animals
  • 3204 Immunology
  • 3101 Biochemistry and cell biology
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
St John, A. L., & Abraham, S. N. (2013). Innate immunity and its regulation by mast cells. J Immunol, 190(9), 4458–4463. https://doi.org/10.4049/jimmunol.1203420
St John, Ashley L., and Soman N. Abraham. “Innate immunity and its regulation by mast cells.J Immunol 190, no. 9 (May 1, 2013): 4458–63. https://doi.org/10.4049/jimmunol.1203420.
St John AL, Abraham SN. Innate immunity and its regulation by mast cells. J Immunol. 2013 May 1;190(9):4458–63.
St John, Ashley L., and Soman N. Abraham. “Innate immunity and its regulation by mast cells.J Immunol, vol. 190, no. 9, May 2013, pp. 4458–63. Pubmed, doi:10.4049/jimmunol.1203420.
St John AL, Abraham SN. Innate immunity and its regulation by mast cells. J Immunol. 2013 May 1;190(9):4458–4463.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

May 1, 2013

Volume

190

Issue

9

Start / End Page

4458 / 4463

Location

United States

Related Subject Headings

  • Mast Cells
  • Inflammation
  • Immunology
  • Immunity, Innate
  • Humans
  • Animals
  • 3204 Immunology
  • 3101 Biochemistry and cell biology
  • 1107 Immunology