Biomarkers for smoking cessation.
Publication
, Journal Article
Bough, KJ; Lerman, C; Rose, JE; McClernon, FJ; Kenny, PJ; Tyndale, RF; David, SP; Stein, EA; Uhl, GR; Conti, DV; Green, C; Amur, S
Published in: Clin Pharmacol Ther
June 2013
One way to enhance therapeutic development is through the identification and development of evaluative tools such as biomarkers. This review focuses on putative diagnostic, pharmacodynamic, and predictive biomarkers for smoking cessation. These types of biomarkers may be used to more accurately diagnose a disease, personalize treatment, identify novel targets for drug discovery, and enhance the efficiency of drug development. Promising biomarkers are presented across a range of approaches including metabolism, genetics, and neuroimaging. A preclinical viewpoint is also offered, as are analytical considerations and a regulatory perspective summarizing a pathway toward biomarker qualification.
Duke Scholars
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Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
June 2013
Volume
93
Issue
6
Start / End Page
526 / 538
Location
United States
Related Subject Headings
- Translational Research, Biomedical
- Smoking Cessation
- Pharmacology & Pharmacy
- Pharmacogenetics
- Neuroimaging
- Humans
- Drug Discovery
- Biomarkers
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Bough, K. J., Lerman, C., Rose, J. E., McClernon, F. J., Kenny, P. J., Tyndale, R. F., … Amur, S. (2013). Biomarkers for smoking cessation. Clin Pharmacol Ther, 93(6), 526–538. https://doi.org/10.1038/clpt.2013.57
Bough, K. J., C. Lerman, J. E. Rose, F. J. McClernon, P. J. Kenny, R. F. Tyndale, S. P. David, et al. “Biomarkers for smoking cessation.” Clin Pharmacol Ther 93, no. 6 (June 2013): 526–38. https://doi.org/10.1038/clpt.2013.57.
Bough KJ, Lerman C, Rose JE, McClernon FJ, Kenny PJ, Tyndale RF, et al. Biomarkers for smoking cessation. Clin Pharmacol Ther. 2013 Jun;93(6):526–38.
Bough, K. J., et al. “Biomarkers for smoking cessation.” Clin Pharmacol Ther, vol. 93, no. 6, June 2013, pp. 526–38. Pubmed, doi:10.1038/clpt.2013.57.
Bough KJ, Lerman C, Rose JE, McClernon FJ, Kenny PJ, Tyndale RF, David SP, Stein EA, Uhl GR, Conti DV, Green C, Amur S. Biomarkers for smoking cessation. Clin Pharmacol Ther. 2013 Jun;93(6):526–538.
Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
June 2013
Volume
93
Issue
6
Start / End Page
526 / 538
Location
United States
Related Subject Headings
- Translational Research, Biomedical
- Smoking Cessation
- Pharmacology & Pharmacy
- Pharmacogenetics
- Neuroimaging
- Humans
- Drug Discovery
- Biomarkers
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences