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Acid phosphatase positivity in childhood acute lymphocytic leukemia.

Publication ,  Journal Article
Head, DR; Borowitz, M; Cerezo, L; Craven, CM; Brock, BL; Boyett, JM; Pullen, DJ; Crist, WM; Falletta, J; Humphrey, GB
Published in: Am J Clin Pathol
November 1986

The Pediatric Oncology Group analyzed 103 cases of childhood acute lymphocytic leukemia (ALL) with an acid phosphatase stain and with a series of immunologic markers. As reported by others, the authors demonstrated a high correlation of acid phosphatase (AP) positivity and T-ALL. However, a subset of T-ALL was acid phosphatase negative, and some non-T, non-B, non-pre-B-ALL cases were AP positive. The predictive value of the AP test was, therefore, poor as a marker of T-ALL. AP-negative T-ALL cases appeared to be a distinctive subset of T-ALL, and AP negativity an intrinsic characteristic of this subset, rather than a failure of the test system. AP-positive n-ALL cases demonstrated no difference from AP-negative cases and, in particular, no evidence of early T-ALL differentiation.

Duke Scholars

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

November 1986

Volume

86

Issue

5

Start / End Page

650 / 653

Location

England

Related Subject Headings

  • Prospective Studies
  • Pathology
  • Leukemia, Lymphoid
  • Humans
  • Child
  • Acid Phosphatase
  • 11 Medical and Health Sciences
 

Citation

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Head, D. R., Borowitz, M., Cerezo, L., Craven, C. M., Brock, B. L., Boyett, J. M., … Humphrey, G. B. (1986). Acid phosphatase positivity in childhood acute lymphocytic leukemia. Am J Clin Pathol, 86(5), 650–653. https://doi.org/10.1093/ajcp/86.5.650
Head, D. R., M. Borowitz, L. Cerezo, C. M. Craven, B. L. Brock, J. M. Boyett, D. J. Pullen, W. M. Crist, J. Falletta, and G. B. Humphrey. “Acid phosphatase positivity in childhood acute lymphocytic leukemia.Am J Clin Pathol 86, no. 5 (November 1986): 650–53. https://doi.org/10.1093/ajcp/86.5.650.
Head DR, Borowitz M, Cerezo L, Craven CM, Brock BL, Boyett JM, et al. Acid phosphatase positivity in childhood acute lymphocytic leukemia. Am J Clin Pathol. 1986 Nov;86(5):650–3.
Head, D. R., et al. “Acid phosphatase positivity in childhood acute lymphocytic leukemia.Am J Clin Pathol, vol. 86, no. 5, Nov. 1986, pp. 650–53. Pubmed, doi:10.1093/ajcp/86.5.650.
Head DR, Borowitz M, Cerezo L, Craven CM, Brock BL, Boyett JM, Pullen DJ, Crist WM, Falletta J, Humphrey GB. Acid phosphatase positivity in childhood acute lymphocytic leukemia. Am J Clin Pathol. 1986 Nov;86(5):650–653.
Journal cover image

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

November 1986

Volume

86

Issue

5

Start / End Page

650 / 653

Location

England

Related Subject Headings

  • Prospective Studies
  • Pathology
  • Leukemia, Lymphoid
  • Humans
  • Child
  • Acid Phosphatase
  • 11 Medical and Health Sciences