Skip to main content

Wild Mandrillus sphinx are carriers of two types of lentivirus.

Publication ,  Journal Article
Souquière, S; Bibollet-Ruche, F; Robertson, DL; Makuwa, M; Apetrei, C; Onanga, R; Kornfeld, C; Plantier, JC; Gao, F; Abernethy, K; White, LJ ...
Published in: J Virol
August 2001

Mandrillus sphinx, a large primate living in Cameroon and Gabon and belonging to the Papionini tribe, was reported to be infected by a simian immunodeficiency virus (SIV) (SIVmndGB1) as early as 1988. Here, we have identified a second, highly divergent SIVmnd (designated SIVmnd-2). Genomic organization differs between the two viral types; SIVmnd-2 has the additional vpx gene, like other SIVs naturally infecting the Papionini tribe (SIVsm and SIVrcm) and in contrast to the other SIVmnd type (here designated SIVmnd-1), which is more closely related to SIVs infecting l'hoest (Cercopithecus lhoesti lhoesti) and sun-tailed (Cercopithecus lhoesti solatus) monkeys. Importantly, our epidemiological studies indicate a high prevalence of both types of SIVmnd; all 10 sexually mature wild-living monkeys and 3 out of 17 wild-born juveniles tested were infected. The geographic distribution of SIVmnd seems to be distinct for the two types: SIVmnd-1 viruses were exclusively identified in mandrills from central and southern Gabon, whereas SIVmnd-2 viruses were identified in monkeys from northern and western Gabon, as well as in Cameroon. SIVmnd-2 full-length sequence analysis, together with analysis of partial sequences from SIVmnd-1 and SIVmnd-2 from wild-born or wild-living mandrills, shows that the gag and pol regions of SIVmnd-2 are closest to those of SIVrcm, isolated from red-capped mangabeys (Cercocebus torquatus), while the env gene is closest to that of SIVmnd-1. pol and env sequence analyses of SIV from a related Papionini species, the drill (Mandrillus leucophaeus), shows a closer relationship of SIVdrl to SIVmnd-2 than to SIVmnd-1. Epidemiological surveys of human immunodeficiency virus revealed a case in Cameroon of a human infected by a virus serologically related to SIVmnd, raising the possibility that mandrills represent a viral reservoir for humans similar to sooty mangabeys in Western Africa and chimpanzees in Central Africa.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 2001

Volume

75

Issue

15

Start / End Page

7086 / 7096

Location

United States

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Recombination, Genetic
  • Phylogeny
  • Peptide Fragments
  • Papio
  • Molecular Sequence Data
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Souquière, S., Bibollet-Ruche, F., Robertson, D. L., Makuwa, M., Apetrei, C., Onanga, R., … Simon, F. (2001). Wild Mandrillus sphinx are carriers of two types of lentivirus. J Virol, 75(15), 7086–7096. https://doi.org/10.1128/JVI.75.15.7086-7096.2001
Souquière, S., F. Bibollet-Ruche, D. L. Robertson, M. Makuwa, C. Apetrei, R. Onanga, C. Kornfeld, et al. “Wild Mandrillus sphinx are carriers of two types of lentivirus.J Virol 75, no. 15 (August 2001): 7086–96. https://doi.org/10.1128/JVI.75.15.7086-7096.2001.
Souquière S, Bibollet-Ruche F, Robertson DL, Makuwa M, Apetrei C, Onanga R, et al. Wild Mandrillus sphinx are carriers of two types of lentivirus. J Virol. 2001 Aug;75(15):7086–96.
Souquière, S., et al. “Wild Mandrillus sphinx are carriers of two types of lentivirus.J Virol, vol. 75, no. 15, Aug. 2001, pp. 7086–96. Pubmed, doi:10.1128/JVI.75.15.7086-7096.2001.
Souquière S, Bibollet-Ruche F, Robertson DL, Makuwa M, Apetrei C, Onanga R, Kornfeld C, Plantier JC, Gao F, Abernethy K, White LJ, Karesh W, Telfer P, Wickings EJ, Mauclère P, Marx PA, Barré-Sinoussi F, Hahn BH, Müller-Trutwin MC, Simon F. Wild Mandrillus sphinx are carriers of two types of lentivirus. J Virol. 2001 Aug;75(15):7086–7096.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 2001

Volume

75

Issue

15

Start / End Page

7086 / 7096

Location

United States

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Recombination, Genetic
  • Phylogeny
  • Peptide Fragments
  • Papio
  • Molecular Sequence Data