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Human infection by genetically diverse SIVSM-related HIV-2 in west Africa.

Publication ,  Journal Article
Gao, F; Yue, L; White, AT; Pappas, PG; Barchue, J; Hanson, AP; Greene, BM; Sharp, PM; Shaw, GM; Hahn, BH
Published in: Nature
August 6, 1992

Our understanding of the biology and origins of human immunodeficiency virus type 2 (HIV-2) derives from studies of cultured isolates from urban populations experiencing epidemic infection and disease. To test the hypothesis that such isolates might represent only a subset of a larger, genetically more diverse group of viruses, we used nested polymerase chain reactions to characterize HIV-2 sequences in uncultured mononuclear blood cells of two healthy Liberian agricultural workers, from whom virus isolation was repeatedly unsuccessful, and from a culture-positive symptomatic urban dweller. Analysis of pol, env and long terminal repeat regions revealed the presence of three highly divergent HIV-2 strains, one of which (from one of the healthy subjects) was significantly more closely related to simian immunodeficiency viruses infecting sooty mangabeys and rhesus macaques (SIVSM/SIVMAC) than to any virus of human derivation. This subject also harboured multiply defective viral genotypes that resulted from hypermutation of G to A bases. Our results indicate that HIV-2, SIVSM and SIVMAC comprise a single, highly diverse group of lentiviruses which cannot be separated into distinct phylogenetic lineages according to species of origin.

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Published In

Nature

DOI

ISSN

0028-0836

Publication Date

August 6, 1992

Volume

358

Issue

6386

Start / End Page

495 / 499

Location

England

Related Subject Headings

  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Phylogeny
  • Molecular Sequence Data
  • Middle Aged
  • Male
  • Liberia
  • Humans
  • HIV-2
  • HIV Long Terminal Repeat
 

Citation

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Gao, F., Yue, L., White, A. T., Pappas, P. G., Barchue, J., Hanson, A. P., … Hahn, B. H. (1992). Human infection by genetically diverse SIVSM-related HIV-2 in west Africa. Nature, 358(6386), 495–499. https://doi.org/10.1038/358495a0
Gao, F., L. Yue, A. T. White, P. G. Pappas, J. Barchue, A. P. Hanson, B. M. Greene, P. M. Sharp, G. M. Shaw, and B. H. Hahn. “Human infection by genetically diverse SIVSM-related HIV-2 in west Africa.Nature 358, no. 6386 (August 6, 1992): 495–99. https://doi.org/10.1038/358495a0.
Gao F, Yue L, White AT, Pappas PG, Barchue J, Hanson AP, et al. Human infection by genetically diverse SIVSM-related HIV-2 in west Africa. Nature. 1992 Aug 6;358(6386):495–9.
Gao, F., et al. “Human infection by genetically diverse SIVSM-related HIV-2 in west Africa.Nature, vol. 358, no. 6386, Aug. 1992, pp. 495–99. Pubmed, doi:10.1038/358495a0.
Gao F, Yue L, White AT, Pappas PG, Barchue J, Hanson AP, Greene BM, Sharp PM, Shaw GM, Hahn BH. Human infection by genetically diverse SIVSM-related HIV-2 in west Africa. Nature. 1992 Aug 6;358(6386):495–499.
Journal cover image

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

August 6, 1992

Volume

358

Issue

6386

Start / End Page

495 / 499

Location

England

Related Subject Headings

  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Phylogeny
  • Molecular Sequence Data
  • Middle Aged
  • Male
  • Liberia
  • Humans
  • HIV-2
  • HIV Long Terminal Repeat