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The tangled circuitry of metabolism and apoptosis.

Publication ,  Journal Article
Andersen, JL; Kornbluth, S
Published in: Molecular cell
February 2013

For single-cell organisms, nutrient uptake and metabolism are central to the fundamental decision of whether to grow or divide. In metazoans, cell fate decisions are more complex: organismal homeostasis must be strictly maintained by balancing cell proliferation and death. Despite this increased complexity, cell fate within multicellular organisms is also influenced by metabolism; recent studies, triggered in part by an interest in tumor metabolism, are beginning to illuminate the mechanisms through which proliferation, death, and metabolism are intertwined. In particular, work on Bcl-2 family proteins suggests that the signaling pathways governing metabolism and apoptosis are inextricably linked. Here we review the crosstalk between these pathways, emphasizing recent work that illustrates the emerging dual nature of several core apoptotic proteins in regulating both metabolism and cell death.

Duke Scholars

Published In

Molecular cell

DOI

EISSN

1097-4164

ISSN

1097-2765

Publication Date

February 2013

Volume

49

Issue

3

Start / End Page

399 / 410

Related Subject Headings

  • Signal Transduction
  • Proto-Oncogene Proteins c-bcl-2
  • Mitochondria
  • Metabolic Networks and Pathways
  • Humans
  • Glucose
  • Developmental Biology
  • Apoptosis
  • Animals
  • 42 Health sciences
 

Citation

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Andersen, J. L., & Kornbluth, S. (2013). The tangled circuitry of metabolism and apoptosis. Molecular Cell, 49(3), 399–410. https://doi.org/10.1016/j.molcel.2012.12.026
Andersen, Joshua L., and Sally Kornbluth. “The tangled circuitry of metabolism and apoptosis.Molecular Cell 49, no. 3 (February 2013): 399–410. https://doi.org/10.1016/j.molcel.2012.12.026.
Andersen JL, Kornbluth S. The tangled circuitry of metabolism and apoptosis. Molecular cell. 2013 Feb;49(3):399–410.
Andersen, Joshua L., and Sally Kornbluth. “The tangled circuitry of metabolism and apoptosis.Molecular Cell, vol. 49, no. 3, Feb. 2013, pp. 399–410. Epmc, doi:10.1016/j.molcel.2012.12.026.
Andersen JL, Kornbluth S. The tangled circuitry of metabolism and apoptosis. Molecular cell. 2013 Feb;49(3):399–410.
Journal cover image

Published In

Molecular cell

DOI

EISSN

1097-4164

ISSN

1097-2765

Publication Date

February 2013

Volume

49

Issue

3

Start / End Page

399 / 410

Related Subject Headings

  • Signal Transduction
  • Proto-Oncogene Proteins c-bcl-2
  • Mitochondria
  • Metabolic Networks and Pathways
  • Humans
  • Glucose
  • Developmental Biology
  • Apoptosis
  • Animals
  • 42 Health sciences