Skip to main content
Journal cover image

Lack of potency of metoclopramide's metabolites in various dopaminergic models

Publication ,  Journal Article
Stanley, M; Wazer, D; Virgilio, J; Kuhn, CM; Benson, DI; Meyerson, LR
Published in: Pharmacology, Biochemistry and Behavior
1983

The dopaminergic properties of metoclopramide and four of its metabolites were determined in a series of in vivo and in vitro tests. In vivo measures included changes in dopamine turnover, serum prolactin levels and antagonism of apomorphine-induced stereotyped behavior. In each of these tests the four metabolites were either completely inactive or significantly less potent than the parent compound. The potency of metoclopramide and its metabolites in in vitro dopamine/neuroleptic receptor models was compared to the potency of standard reference compounds. In vitro results indicate that none of the four metabolites tested had antagonist activity in any of the receptor models in which they were evaluated. These findings will be discussed in light of the current understanding of receptor models as they relate to antipsychotic efficacy. © 1983.

Duke Scholars

Published In

Pharmacology, Biochemistry and Behavior

ISSN

0091-3057

Publication Date

1983

Volume

18

Issue

2

Start / End Page

263 / 266

Related Subject Headings

  • Neurology & Neurosurgery
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Stanley, M., Wazer, D., Virgilio, J., Kuhn, C. M., Benson, D. I., & Meyerson, L. R. (1983). Lack of potency of metoclopramide's metabolites in various dopaminergic models. Pharmacology, Biochemistry and Behavior, 18(2), 263–266.
Stanley, M., D. Wazer, J. Virgilio, C. M. Kuhn, D. I. Benson, and L. R. Meyerson. “Lack of potency of metoclopramide's metabolites in various dopaminergic models.” Pharmacology, Biochemistry and Behavior 18, no. 2 (1983): 263–66.
Stanley M, Wazer D, Virgilio J, Kuhn CM, Benson DI, Meyerson LR. Lack of potency of metoclopramide's metabolites in various dopaminergic models. Pharmacology, Biochemistry and Behavior. 1983;18(2):263–6.
Stanley, M., et al. “Lack of potency of metoclopramide's metabolites in various dopaminergic models.” Pharmacology, Biochemistry and Behavior, vol. 18, no. 2, 1983, pp. 263–66.
Stanley M, Wazer D, Virgilio J, Kuhn CM, Benson DI, Meyerson LR. Lack of potency of metoclopramide's metabolites in various dopaminergic models. Pharmacology, Biochemistry and Behavior. 1983;18(2):263–266.
Journal cover image

Published In

Pharmacology, Biochemistry and Behavior

ISSN

0091-3057

Publication Date

1983

Volume

18

Issue

2

Start / End Page

263 / 266

Related Subject Headings

  • Neurology & Neurosurgery
  • 1115 Pharmacology and Pharmaceutical Sciences