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An inhibitory role for brain serotonin containing systems in the locomotor effects of d amphetamine

Publication ,  Journal Article
Hollister, AS; Breese, GR; Kuhn, CM; Cooper, BR; Schanberg, SM
Published in: Journal of Pharmacology and Experimental Therapeutics
1976

Locomotor activity induced by d amphetamine was found to be potentiated by food deprivation, a tryptophan free diet, p chlorophenylalanine and drugs proposed to antagonize serotonin receptors in brain. Administration of L tryptophan 1 hour prior to d amphetamine injection was found to antagonize the enhanced response to d amphetamine in starved rats and in rats which had tryptophan removed from their diet. However, tryptophan did not block the potentiated response to d amphetamine in animals pretreated with p chlorophenylalanine. These findings suggested that the antagonism of d amphetamine induced activity by tryptophan in starved rats and rats fed a tryptophan free diet was not due to a nonspecific depressant effect of the amino acid. Since accumulation of d amphetamine and its metabolites was not affected by any of the treatments which enhanced its activity, it seems unlikely that an alteration in the metabolism of d amphetamine can explain these findings. The present work provides additional support for the view that serotonergic fibers play an important role in the actions of d amphetamine.

Duke Scholars

Published In

Journal of Pharmacology and Experimental Therapeutics

ISSN

0022-3565

Publication Date

1976

Volume

198

Issue

1

Start / End Page

12 / 22

Related Subject Headings

  • Pharmacology & Pharmacy
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Hollister, A. S., Breese, G. R., Kuhn, C. M., Cooper, B. R., & Schanberg, S. M. (1976). An inhibitory role for brain serotonin containing systems in the locomotor effects of d amphetamine. Journal of Pharmacology and Experimental Therapeutics, 198(1), 12–22.
Hollister, A. S., G. R. Breese, C. M. Kuhn, B. R. Cooper, and S. M. Schanberg. “An inhibitory role for brain serotonin containing systems in the locomotor effects of d amphetamine.” Journal of Pharmacology and Experimental Therapeutics 198, no. 1 (1976): 12–22.
Hollister AS, Breese GR, Kuhn CM, Cooper BR, Schanberg SM. An inhibitory role for brain serotonin containing systems in the locomotor effects of d amphetamine. Journal of Pharmacology and Experimental Therapeutics. 1976;198(1):12–22.
Hollister, A. S., et al. “An inhibitory role for brain serotonin containing systems in the locomotor effects of d amphetamine.” Journal of Pharmacology and Experimental Therapeutics, vol. 198, no. 1, 1976, pp. 12–22.
Hollister AS, Breese GR, Kuhn CM, Cooper BR, Schanberg SM. An inhibitory role for brain serotonin containing systems in the locomotor effects of d amphetamine. Journal of Pharmacology and Experimental Therapeutics. 1976;198(1):12–22.

Published In

Journal of Pharmacology and Experimental Therapeutics

ISSN

0022-3565

Publication Date

1976

Volume

198

Issue

1

Start / End Page

12 / 22

Related Subject Headings

  • Pharmacology & Pharmacy
  • 1115 Pharmacology and Pharmaceutical Sciences