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Assessing applicability when comparing medical interventions: AHRQ and the Effective Health Care Program.

Publication ,  Journal Article
Atkins, D; Chang, SM; Gartlehner, G; Buckley, DI; Whitlock, EP; Berliner, E; Matchar, D
Published in: J Clin Epidemiol
November 2011

OBJECTIVE: To describe a systematic approach for identifying, reporting, and synthesizing information to allow consistent and transparent consideration of the applicability of the evidence in a systematic review according to the Population, Intervention, Comparator, Outcome, Setting domains. STUDY DESIGN AND SETTING: Comparative effectiveness reviews need to consider whether available evidence is applicable to specific clinical or policy questions to be useful to decision makers. Authors reviewed the literature and developed guidance for the Effective Health Care program. RESULTS: Because applicability depends on the specific questions and needs of the users, it is difficult to devise a valid uniform scale for rating the overall applicability of individual studies or body of evidence. We recommend consulting stakeholders to identify the factors most relevant to applicability for their decisions. Applicability should be considered separately for benefits and harms. Observational studies can help determine whether trial populations and interventions are representative of "real world" practice. Reviewers should describe differences between available evidence and the ideally applicable evidence for the question being asked and offer a qualitative judgment about the importance and potential effect of those differences. CONCLUSION: Careful consideration of applicability may improve the usefulness of systematic reviews in informing practice and policy.

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Published In

J Clin Epidemiol

DOI

EISSN

1878-5921

Publication Date

November 2011

Volume

64

Issue

11

Start / End Page

1198 / 1207

Location

United States

Related Subject Headings

  • United States Agency for Healthcare Research and Quality
  • United States
  • Review Literature as Topic
  • Research Design
  • Policy Making
  • Outcome Assessment, Health Care
  • Middle Aged
  • Male
  • Humans
  • Guidelines as Topic
 

Citation

APA
Chicago
ICMJE
MLA
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Atkins, D., Chang, S. M., Gartlehner, G., Buckley, D. I., Whitlock, E. P., Berliner, E., & Matchar, D. (2011). Assessing applicability when comparing medical interventions: AHRQ and the Effective Health Care Program. J Clin Epidemiol, 64(11), 1198–1207. https://doi.org/10.1016/j.jclinepi.2010.11.021
Atkins, David, Stephanie M. Chang, Gerald Gartlehner, David I. Buckley, Evelyn P. Whitlock, Elise Berliner, and David Matchar. “Assessing applicability when comparing medical interventions: AHRQ and the Effective Health Care Program.J Clin Epidemiol 64, no. 11 (November 2011): 1198–1207. https://doi.org/10.1016/j.jclinepi.2010.11.021.
Atkins D, Chang SM, Gartlehner G, Buckley DI, Whitlock EP, Berliner E, et al. Assessing applicability when comparing medical interventions: AHRQ and the Effective Health Care Program. J Clin Epidemiol. 2011 Nov;64(11):1198–207.
Atkins, David, et al. “Assessing applicability when comparing medical interventions: AHRQ and the Effective Health Care Program.J Clin Epidemiol, vol. 64, no. 11, Nov. 2011, pp. 1198–207. Pubmed, doi:10.1016/j.jclinepi.2010.11.021.
Atkins D, Chang SM, Gartlehner G, Buckley DI, Whitlock EP, Berliner E, Matchar D. Assessing applicability when comparing medical interventions: AHRQ and the Effective Health Care Program. J Clin Epidemiol. 2011 Nov;64(11):1198–1207.
Journal cover image

Published In

J Clin Epidemiol

DOI

EISSN

1878-5921

Publication Date

November 2011

Volume

64

Issue

11

Start / End Page

1198 / 1207

Location

United States

Related Subject Headings

  • United States Agency for Healthcare Research and Quality
  • United States
  • Review Literature as Topic
  • Research Design
  • Policy Making
  • Outcome Assessment, Health Care
  • Middle Aged
  • Male
  • Humans
  • Guidelines as Topic