Skip to main content

Direct ultrastructural evidence of target-directed polarization by cytotoxic lymphocytes in lesions of human graft-vs-host disease.

Publication ,  Journal Article
Sale, GE; Gallucci, BB; Schubert, MM; Sullivan, KM; Thomas, ED
Published in: Arch Pathol Lab Med
April 1987

Cytotoxic lymphocytes are thought to kill target cells by means of potent cytotoxic granules that congregate near the microtubular organizing center and the Golgi apparatus at one pole of the killer cell. We searched for evidence of this type of polarization in 12 lip biopsy specimens from patients with acute and/or chronic graft-vs-host disease (GVHD) compared with two lip specimens from normal individuals. Lymphocytes with such polarization were found in contact with epithelial cells of the squamous mucosa in all 12 cases of GVHD, and cells of the cuboidal minor salivary duct epithelium were found in two of 11 evaluable cases. The data add support to the hypothesis that cytolytic lymphocytes attack epithelial cells in GVHD.

Duke Scholars

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

April 1987

Volume

111

Issue

4

Start / End Page

333 / 336

Location

United States

Related Subject Headings

  • T-Lymphocytes, Cytotoxic
  • Salivary Glands
  • Pathology
  • Middle Aged
  • Microtubules
  • Killer Cells, Natural
  • Humans
  • Graft vs Host Disease
  • Golgi Apparatus
  • Epithelium
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sale, G. E., Gallucci, B. B., Schubert, M. M., Sullivan, K. M., & Thomas, E. D. (1987). Direct ultrastructural evidence of target-directed polarization by cytotoxic lymphocytes in lesions of human graft-vs-host disease. Arch Pathol Lab Med, 111(4), 333–336.
Sale, G. E., B. B. Gallucci, M. M. Schubert, K. M. Sullivan, and E. D. Thomas. “Direct ultrastructural evidence of target-directed polarization by cytotoxic lymphocytes in lesions of human graft-vs-host disease.Arch Pathol Lab Med 111, no. 4 (April 1987): 333–36.
Sale GE, Gallucci BB, Schubert MM, Sullivan KM, Thomas ED. Direct ultrastructural evidence of target-directed polarization by cytotoxic lymphocytes in lesions of human graft-vs-host disease. Arch Pathol Lab Med. 1987 Apr;111(4):333–6.
Sale, G. E., et al. “Direct ultrastructural evidence of target-directed polarization by cytotoxic lymphocytes in lesions of human graft-vs-host disease.Arch Pathol Lab Med, vol. 111, no. 4, Apr. 1987, pp. 333–36.
Sale GE, Gallucci BB, Schubert MM, Sullivan KM, Thomas ED. Direct ultrastructural evidence of target-directed polarization by cytotoxic lymphocytes in lesions of human graft-vs-host disease. Arch Pathol Lab Med. 1987 Apr;111(4):333–336.

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

April 1987

Volume

111

Issue

4

Start / End Page

333 / 336

Location

United States

Related Subject Headings

  • T-Lymphocytes, Cytotoxic
  • Salivary Glands
  • Pathology
  • Middle Aged
  • Microtubules
  • Killer Cells, Natural
  • Humans
  • Graft vs Host Disease
  • Golgi Apparatus
  • Epithelium