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Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.

Publication ,  Journal Article
Nemeroff, CB; Owens, MJ; Bissette, G; Andorn, AC; Stanley, M
Published in: Arch Gen Psychiatry
June 1988

Previous studies have provided evidence that corticotropin releasing factor (CRF) is hypersecreted in patients with major depression. This CRF hypersecretion is believed to contribute at least in part to hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients. If CRF is chronically hypersecreted in depressed patients, then, due to down-regulation, a reduced number of CRF receptor binding sites should be present in patients with profound depressive disorder. To test this hypothesis, we measured the number and affinity of CRF binding sites in the frontal cortex of 26 suicide victims and 29 controls who died of a variety of causes. There was a marked (23%) reduction in the number of CRF binding sites in the frontal cortex of the suicide victims compared with the controls. These data are consistent with the hypothesis that CRF is hypersecreted in depression.

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Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

June 1988

Volume

45

Issue

6

Start / End Page

577 / 579

Location

United States

Related Subject Headings

  • Suicide
  • Receptors, Neurotransmitter
  • Receptors, Corticotropin-Releasing Hormone
  • Psychiatry
  • Pituitary-Adrenal System
  • Male
  • Hypothalamo-Hypophyseal System
  • Humans
  • Frontal Lobe
  • Female
 

Citation

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Nemeroff, C. B., Owens, M. J., Bissette, G., Andorn, A. C., & Stanley, M. (1988). Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry, 45(6), 577–579. https://doi.org/10.1001/archpsyc.1988.01800300075009
Nemeroff, C. B., M. J. Owens, G. Bissette, A. C. Andorn, and M. Stanley. “Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.Arch Gen Psychiatry 45, no. 6 (June 1988): 577–79. https://doi.org/10.1001/archpsyc.1988.01800300075009.
Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry. 1988 Jun;45(6):577–9.
Nemeroff, C. B., et al. “Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.Arch Gen Psychiatry, vol. 45, no. 6, June 1988, pp. 577–79. Pubmed, doi:10.1001/archpsyc.1988.01800300075009.
Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry. 1988 Jun;45(6):577–579.

Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

June 1988

Volume

45

Issue

6

Start / End Page

577 / 579

Location

United States

Related Subject Headings

  • Suicide
  • Receptors, Neurotransmitter
  • Receptors, Corticotropin-Releasing Hormone
  • Psychiatry
  • Pituitary-Adrenal System
  • Male
  • Hypothalamo-Hypophyseal System
  • Humans
  • Frontal Lobe
  • Female