Skip to main content

Evidence for selective expression of the p53 codon 72 polymorphs: Implications in cancer development

Publication ,  Journal Article
Siddique, MM; Balram, C; Fiszer-Maliszewska, L; Aggarwal, A; Tan, A; Tan, P; Soo, KC; Sabapathy, K
Published in: Cancer Epidemiology Biomarkers and Prevention
2005

Polymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial. We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects. Asians were found to preferentially express the pro allele whereas the Caucasians preferentially express the arg allele. On the contrary, about 75% of the heterozygote Chinese breast cancer patients preferentially expressed the arg allele, which rarely contained any somatic mutations. Moreover, histologically normal tissues from Chinese heterozygote breast cancer patients showed selective expression of the arg allele, in contrast to the preferential expression of the pro allele in heterozygote healthy normal breast tissues. Together, the data suggest that the expression of the different p53 polymorphs is selectively regulated in different ethnic populations, and that the arg allele is activated during cancer development in Asians. Thus, the expression status of the p53 polymorphs, rather than the genotypic status, might be a useful indicator for cancer susceptibility. Copyright © 2005 American Association for Cancer Research.

Duke Scholars

Published In

Cancer Epidemiology Biomarkers and Prevention

DOI

ISSN

1055-9965

Publication Date

2005

Volume

14

Issue

9

Start / End Page

2245 / 2252

Related Subject Headings

  • Epidemiology
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Siddique, M. M., Balram, C., Fiszer-Maliszewska, L., Aggarwal, A., Tan, A., Tan, P., … Sabapathy, K. (2005). Evidence for selective expression of the p53 codon 72 polymorphs: Implications in cancer development. Cancer Epidemiology Biomarkers and Prevention, 14(9), 2245–2252. https://doi.org/10.1158/1055-9965.EPI-05-0153
Siddique, M. M., C. Balram, L. Fiszer-Maliszewska, A. Aggarwal, A. Tan, P. Tan, K. C. Soo, and K. Sabapathy. “Evidence for selective expression of the p53 codon 72 polymorphs: Implications in cancer development.” Cancer Epidemiology Biomarkers and Prevention 14, no. 9 (2005): 2245–52. https://doi.org/10.1158/1055-9965.EPI-05-0153.
Siddique MM, Balram C, Fiszer-Maliszewska L, Aggarwal A, Tan A, Tan P, et al. Evidence for selective expression of the p53 codon 72 polymorphs: Implications in cancer development. Cancer Epidemiology Biomarkers and Prevention. 2005;14(9):2245–52.
Siddique, M. M., et al. “Evidence for selective expression of the p53 codon 72 polymorphs: Implications in cancer development.” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 9, 2005, pp. 2245–52. Scival, doi:10.1158/1055-9965.EPI-05-0153.
Siddique MM, Balram C, Fiszer-Maliszewska L, Aggarwal A, Tan A, Tan P, Soo KC, Sabapathy K. Evidence for selective expression of the p53 codon 72 polymorphs: Implications in cancer development. Cancer Epidemiology Biomarkers and Prevention. 2005;14(9):2245–2252.

Published In

Cancer Epidemiology Biomarkers and Prevention

DOI

ISSN

1055-9965

Publication Date

2005

Volume

14

Issue

9

Start / End Page

2245 / 2252

Related Subject Headings

  • Epidemiology
  • 11 Medical and Health Sciences