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Integrating database information in microarray expression analyses: Application to melanoma cell lines profiled in the NCI60 data set.

Publication ,  Journal Article
Dang, H; Le, T; Segaran, T; Levy, J
Published in: Journal of biomolecular techniques : JBT
December 2002

A series of successful microarray experiments typically results in a data matrix containing a list of a few thousand genes and their measured expression values across various conditions tested. The understanding of why some genes are clustered in their expression pattern can be greatly facilitated by gathering all prior knowledge about all the genes in a given cluster. Here we demonstrate a strategy using the NCI60 data set (Scherf U, Ross DT,Waltham M, et al., Nature Genet 2000;24(3):236-244) on a cluster of genes highly expressed in the melanoma cell lines. By traversing public databases using cross-references between the databases,we show that the Gene Ontology (GO) classifications of some of the genes are consistent with their products' involvement in melanin biosynthesis.

Duke Scholars

Published In

Journal of biomolecular techniques : JBT

EISSN

1943-4731

ISSN

1524-0215

Publication Date

December 2002

Volume

13

Issue

4

Start / End Page

199 / 204

Related Subject Headings

  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 10 Technology
  • 06 Biological Sciences
 

Citation

APA
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ICMJE
MLA
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Dang, H., Le, T., Segaran, T., & Levy, J. (2002). Integrating database information in microarray expression analyses: Application to melanoma cell lines profiled in the NCI60 data set. Journal of Biomolecular Techniques : JBT, 13(4), 199–204.
Dang, Hong, Tin Le, Toby Segaran, and Joshua Levy. “Integrating database information in microarray expression analyses: Application to melanoma cell lines profiled in the NCI60 data set.Journal of Biomolecular Techniques : JBT 13, no. 4 (December 2002): 199–204.
Dang H, Le T, Segaran T, Levy J. Integrating database information in microarray expression analyses: Application to melanoma cell lines profiled in the NCI60 data set. Journal of biomolecular techniques : JBT. 2002 Dec;13(4):199–204.
Dang, Hong, et al. “Integrating database information in microarray expression analyses: Application to melanoma cell lines profiled in the NCI60 data set.Journal of Biomolecular Techniques : JBT, vol. 13, no. 4, Dec. 2002, pp. 199–204.
Dang H, Le T, Segaran T, Levy J. Integrating database information in microarray expression analyses: Application to melanoma cell lines profiled in the NCI60 data set. Journal of biomolecular techniques : JBT. 2002 Dec;13(4):199–204.

Published In

Journal of biomolecular techniques : JBT

EISSN

1943-4731

ISSN

1524-0215

Publication Date

December 2002

Volume

13

Issue

4

Start / End Page

199 / 204

Related Subject Headings

  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 10 Technology
  • 06 Biological Sciences