An MCell model of calcium dynamics and frequency-dependence of calmodulin activation in dendritic spines
Pairing action potentials in synaptically coupled cortical pyramidal cells induces LTP in a frequency-dependent manner (H. Markram et al., Science 275 (1997) 213). Using Mcell, which simulated the 3D geometry of the spine and the diffusion and binding of Ca 2+, we show that pairing five EPSPs and back-propagating action potentials results in a Ca 2+ influx into a model dendritic spine that is largely frequency independent but leads to a frequency-dependent activation of postsynaptic calmodulin. Furthermore, we show how altering the availability of calmodulin and the calcium-binding capacity can alter the efficacy and potency of the frequency-response curve. The model shows how the cell can regulate its plasticity by buffering Ca 2+ signals. © 2001 Elsevier Science B.V. All rights reserved.
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- Artificial Intelligence & Image Processing
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Citation
Published In
DOI
ISSN
Publication Date
Volume
Start / End Page
Related Subject Headings
- Artificial Intelligence & Image Processing
- 52 Psychology
- 46 Information and computing sciences
- 40 Engineering
- 17 Psychology and Cognitive Sciences
- 09 Engineering
- 08 Information and Computing Sciences