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Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain.

Publication ,  Journal Article
Ghasia, FF; Freedman, SF; Rajani, A; Holgado, S; Asrani, S; El-Dairi, M
Published in: Br J Ophthalmol
July 2013

BACKGROUND/AIMS: Spectral-domain (SD)- Optical Coherence Tomography (OCT) can track eye movements, has faster acquisition time and higher resolution than time-domain(TD)-OCT. The aim of the study was to assess the utility of SD-OCT in paediatric glaucoma and determine its agreement with TD-OCT. METHODS: Children who had SD-OCT(Spectralis, Heidelberg-Engineering,Germany) were retrospectively and prospectively identified from Duke paediatric glaucoma clinic. The peripapillary retinal nerve fibre layer (RNFL) and macular thickness and volume (MV) were compared amongst four groups: normal eyes, eyes with physiologic cupping (C:D >0.5 and <0.8, IOP <21), mild glaucomatous eyes (C:D <0.5, intra-ocular pressure (IOP) >21) and severe glaucoma (C:D>0.5, IOP>21). SD-OCT values were compared to TD-OCT(OCT-3, Carl-Zeiss-Meditec, Dublin, CA) values in a subset of subjects who had same day scans using both instruments. Children with neurologic disorders, refractive error >±5D, pseudophakia and prematurity were excluded. RESULTS: Included were 83 eyes of 83 children, mean age 11.9 ± 4.2 years. SD-OCT measurements of average RNFL thickness and MV differed among normals(n=24), physiologically cupped (n=31), mild (n=15) versus severe glaucoma (n=13): (RNFL:104 ± 9, 99 ± 6, 98 ± 9 vs 62 ± 18 µm, respectively, p<0.05; MV: 8.7 ± 0.3, 8.6 ± 0.3, 8.8 ± 0.4 vs 8.0 ± 0.6 mm³;, respectively, p<0.05). Same-day SD-OCT and TD-OCT measures in 53 eyes correlated linearly (RNFL r(2)=0.88; MVr(2)=0.58). SD-OCT measured lower RNFL and higher macular thickness than TD-OCT. Among eyes with severe glaucoma, 4 of 13 (30%) had unreliable TD-OCT but reliable SD-OCT. CONCLUSIONS: SD-OCT was easier to obtain than TD-OCT in children. SD-OCT and TD-OCT measurements correlated, but values were not interchangeable.

Duke Scholars

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

July 2013

Volume

97

Issue

7

Start / End Page

837 / 842

Location

England

Related Subject Headings

  • Young Adult
  • Visual Fields
  • Tonometry, Ocular
  • Tomography, Optical Coherence
  • Retrospective Studies
  • Retinal Ganglion Cells
  • Reproducibility of Results
  • Prospective Studies
  • Optic Nerve Diseases
  • Optic Disk
 

Citation

APA
Chicago
ICMJE
MLA
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Ghasia, F. F., Freedman, S. F., Rajani, A., Holgado, S., Asrani, S., & El-Dairi, M. (2013). Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain. Br J Ophthalmol, 97(7), 837–842. https://doi.org/10.1136/bjophthalmol-2012-302648
Ghasia, Fatema F., Sharon F. Freedman, Anand Rajani, Sandra Holgado, Sanjay Asrani, and Mays El-Dairi. “Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain.Br J Ophthalmol 97, no. 7 (July 2013): 837–42. https://doi.org/10.1136/bjophthalmol-2012-302648.
Ghasia FF, Freedman SF, Rajani A, Holgado S, Asrani S, El-Dairi M. Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain. Br J Ophthalmol. 2013 Jul;97(7):837–42.
Ghasia, Fatema F., et al. “Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain.Br J Ophthalmol, vol. 97, no. 7, July 2013, pp. 837–42. Pubmed, doi:10.1136/bjophthalmol-2012-302648.
Ghasia FF, Freedman SF, Rajani A, Holgado S, Asrani S, El-Dairi M. Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain. Br J Ophthalmol. 2013 Jul;97(7):837–842.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

July 2013

Volume

97

Issue

7

Start / End Page

837 / 842

Location

England

Related Subject Headings

  • Young Adult
  • Visual Fields
  • Tonometry, Ocular
  • Tomography, Optical Coherence
  • Retrospective Studies
  • Retinal Ganglion Cells
  • Reproducibility of Results
  • Prospective Studies
  • Optic Nerve Diseases
  • Optic Disk