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Functional specialization of mouse higher visual cortical areas.

Publication ,  Journal Article
Andermann, ML; Kerlin, AM; Roumis, DK; Glickfeld, LL; Reid, RC
Published in: Neuron
December 22, 2011

The mouse is emerging as an important model for understanding how sensory neocortex extracts cues to guide behavior, yet little is known about how these cues are processed beyond primary cortical areas. Here, we used two-photon calcium imaging in awake mice to compare visual responses in primary visual cortex (V1) and in two downstream target areas, AL and PM. Neighboring V1 neurons had diverse stimulus preferences spanning five octaves in spatial and temporal frequency. By contrast, AL and PM neurons responded best to distinct ranges of stimulus parameters. Most strikingly, AL neurons preferred fast-moving stimuli while PM neurons preferred slow-moving stimuli. By contrast, neurons in V1, AL, and PM demonstrated similar selectivity for stimulus orientation but not for stimulus direction. Based on these findings, we predict that area AL helps guide behaviors involving fast-moving stimuli (e.g., optic flow), while area PM helps guide behaviors involving slow-moving objects.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 22, 2011

Volume

72

Issue

6

Start / End Page

1025 / 1039

Location

United States

Related Subject Headings

  • Visual Pathways
  • Visual Cortex
  • Photic Stimulation
  • Neurology & Neurosurgery
  • Motion Perception
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Female
  • Brain Mapping
 

Citation

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Andermann, M. L., Kerlin, A. M., Roumis, D. K., Glickfeld, L. L., & Reid, R. C. (2011). Functional specialization of mouse higher visual cortical areas. Neuron, 72(6), 1025–1039. https://doi.org/10.1016/j.neuron.2011.11.013
Andermann, Mark L., Aaron M. Kerlin, Demetris K. Roumis, Lindsey L. Glickfeld, and R Clay Reid. “Functional specialization of mouse higher visual cortical areas.Neuron 72, no. 6 (December 22, 2011): 1025–39. https://doi.org/10.1016/j.neuron.2011.11.013.
Andermann ML, Kerlin AM, Roumis DK, Glickfeld LL, Reid RC. Functional specialization of mouse higher visual cortical areas. Neuron. 2011 Dec 22;72(6):1025–39.
Andermann, Mark L., et al. “Functional specialization of mouse higher visual cortical areas.Neuron, vol. 72, no. 6, Dec. 2011, pp. 1025–39. Pubmed, doi:10.1016/j.neuron.2011.11.013.
Andermann ML, Kerlin AM, Roumis DK, Glickfeld LL, Reid RC. Functional specialization of mouse higher visual cortical areas. Neuron. 2011 Dec 22;72(6):1025–1039.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 22, 2011

Volume

72

Issue

6

Start / End Page

1025 / 1039

Location

United States

Related Subject Headings

  • Visual Pathways
  • Visual Cortex
  • Photic Stimulation
  • Neurology & Neurosurgery
  • Motion Perception
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Female
  • Brain Mapping