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Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex.

Publication ,  Journal Article
Kapfer, C; Glickfeld, LL; Atallah, BV; Scanziani, M
Published in: Nat Neurosci
June 2007

The balance between excitation and inhibition in the cortex is crucial in determining sensory processing. Because the amount of excitation varies, maintaining this balance is a dynamic process; yet the underlying mechanisms are poorly understood. We show here that the activity of even a single layer 2/3 pyramidal cell in the somatosensory cortex of the rat generates widespread inhibition that increases disproportionately with the number of active pyramidal neurons. This supralinear increase of inhibition results from the incremental recruitment of somatostatin-expressing inhibitory interneurons located in layers 2/3 and 5. The recruitment of these interneurons increases tenfold when they are excited by two pyramidal cells. A simple model demonstrates that the distribution of excitatory input amplitudes onto inhibitory neurons influences the sensitivity and dynamic range of the recurrent circuit. These data show that through a highly sensitive recurrent inhibitory circuit, cortical excitability can be modulated by one pyramidal cell.

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Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

June 2007

Volume

10

Issue

6

Start / End Page

743 / 753

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Rats
  • Quinoxalines
  • Pyramidal Cells
  • Patch-Clamp Techniques
  • Neurology & Neurosurgery
  • Neural Inhibition
  • Nerve Net
  • Models, Neurological
  • In Vitro Techniques
 

Citation

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Kapfer, C., Glickfeld, L. L., Atallah, B. V., & Scanziani, M. (2007). Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. Nat Neurosci, 10(6), 743–753. https://doi.org/10.1038/nn1909
Kapfer, Christoph, Lindsey L. Glickfeld, Bassam V. Atallah, and Massimo Scanziani. “Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex.Nat Neurosci 10, no. 6 (June 2007): 743–53. https://doi.org/10.1038/nn1909.
Kapfer C, Glickfeld LL, Atallah BV, Scanziani M. Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. Nat Neurosci. 2007 Jun;10(6):743–53.
Kapfer, Christoph, et al. “Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex.Nat Neurosci, vol. 10, no. 6, June 2007, pp. 743–53. Pubmed, doi:10.1038/nn1909.
Kapfer C, Glickfeld LL, Atallah BV, Scanziani M. Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. Nat Neurosci. 2007 Jun;10(6):743–753.

Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

June 2007

Volume

10

Issue

6

Start / End Page

743 / 753

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Rats
  • Quinoxalines
  • Pyramidal Cells
  • Patch-Clamp Techniques
  • Neurology & Neurosurgery
  • Neural Inhibition
  • Nerve Net
  • Models, Neurological
  • In Vitro Techniques