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Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells.

Publication ,  Journal Article
Glickfeld, LL; Scanziani, M
Published in: Nat Neurosci
June 2006

Cannabinoids are powerful modulators of inhibition, yet the precise spike timing of cannabinoid receptor (CB1R)-expressing inhibitory neurons in relation to other neurons in the circuit is poorly understood. Here we found that the spike timing of CB1R-expressing basket cells, a major target for cannabinoids in the rat hippocampus, was distinct from the other main group of basket cells, the CB1R-negative. Despite receiving the same afferent inputs, the synaptic and biophysical properties of the two cell types were tuned to detect different features of activity. CB1R-negative basket cells responded reliably and immediately to subtle and repetitive excitation. In contrast, CB1R-positive basket cells responded later and did not follow repetitive activity, but were better suited to integrate the consecutive excitation of independent afferents. This temporal separation in the activity of the two basket cell types generated distinct epochs of somatic inhibition that were differentially affected by endocannabinoids.

Duke Scholars

Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

June 2006

Volume

9

Issue

6

Start / End Page

807 / 815

Location

United States

Related Subject Headings

  • Time Factors
  • Synaptic Transmission
  • Synapses
  • Receptor, Cannabinoid, CB1
  • Reaction Time
  • Rats, Wistar
  • Rats
  • Pyramidal Cells
  • Patch-Clamp Techniques
  • Organ Culture Techniques
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Glickfeld, L. L., & Scanziani, M. (2006). Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells. Nat Neurosci, 9(6), 807–815. https://doi.org/10.1038/nn1688
Glickfeld, Lindsey L., and Massimo Scanziani. “Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells.Nat Neurosci 9, no. 6 (June 2006): 807–15. https://doi.org/10.1038/nn1688.
Glickfeld, Lindsey L., and Massimo Scanziani. “Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells.Nat Neurosci, vol. 9, no. 6, June 2006, pp. 807–15. Pubmed, doi:10.1038/nn1688.
Glickfeld LL, Scanziani M. Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells. Nat Neurosci. 2006 Jun;9(6):807–815.

Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

June 2006

Volume

9

Issue

6

Start / End Page

807 / 815

Location

United States

Related Subject Headings

  • Time Factors
  • Synaptic Transmission
  • Synapses
  • Receptor, Cannabinoid, CB1
  • Reaction Time
  • Rats, Wistar
  • Rats
  • Pyramidal Cells
  • Patch-Clamp Techniques
  • Organ Culture Techniques