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Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis.

Publication ,  Journal Article
St John, AL; Abraham, SN; Gubler, DJ
Published in: Nat Rev Microbiol
June 2013

Dengue virus (DENV) is a human pathogen that causes severe and potentially fatal disease in millions of individuals each year. Immune-mediated pathology is thought to underlie many of the complications of DENV infection in humans, but the notable limitations of the available animal models have impeded our knowledge of the interactions between DENV and the immune system. In this Opinion article, we discuss some of the controversies in the field of dengue research relating to the interaction between DENV and the mammalian host. We highlight key barriers hindering our understanding of the molecular pathogenesis of DENV and offer suggestions for the most effective ways in which the role of the immune system in the protection from, and pathology of, DENV infection can be addressed experimentally.

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Published In

Nat Rev Microbiol

DOI

EISSN

1740-1534

Publication Date

June 2013

Volume

11

Issue

6

Start / End Page

420 / 426

Location

England

Related Subject Headings

  • Risk Factors
  • Microbiology
  • Insect Vectors
  • Humans
  • Host-Pathogen Interactions
  • Dengue Virus
  • Dengue
  • Animals
  • Aedes
  • 3107 Microbiology
 

Citation

APA
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ICMJE
MLA
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St John, A. L., Abraham, S. N., & Gubler, D. J. (2013). Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis. Nat Rev Microbiol, 11(6), 420–426. https://doi.org/10.1038/nrmicro3030
St John, Ashley L., Soman N. Abraham, and Duane J. Gubler. “Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis.Nat Rev Microbiol 11, no. 6 (June 2013): 420–26. https://doi.org/10.1038/nrmicro3030.
St John AL, Abraham SN, Gubler DJ. Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis. Nat Rev Microbiol. 2013 Jun;11(6):420–6.
St John, Ashley L., et al. “Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis.Nat Rev Microbiol, vol. 11, no. 6, June 2013, pp. 420–26. Pubmed, doi:10.1038/nrmicro3030.
St John AL, Abraham SN, Gubler DJ. Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis. Nat Rev Microbiol. 2013 Jun;11(6):420–426.

Published In

Nat Rev Microbiol

DOI

EISSN

1740-1534

Publication Date

June 2013

Volume

11

Issue

6

Start / End Page

420 / 426

Location

England

Related Subject Headings

  • Risk Factors
  • Microbiology
  • Insect Vectors
  • Humans
  • Host-Pathogen Interactions
  • Dengue Virus
  • Dengue
  • Animals
  • Aedes
  • 3107 Microbiology