Skip to main content
Journal cover image

Effects of Y27632 on keratinocyte procurement and wound healing.

Publication ,  Journal Article
Gandham, VD; Maddala, RL; Rao, V; Jin, JY; Epstein, DL; Hall, RP; Zhang, JY
Published in: Clin Exp Dermatol
October 2013

A number of Rho-kinase inhibitors have been developed for various clinical applications. We examined the effects of the Rho-kinase inhibitor Y27632 on keratinocyte proliferation and migration, and found that it promoted primary human keratinocyte proliferation and migration in both monolayer and skin explant cultures. In addition, topical application of Y27632 enhanced cutaneous wound closure in the majority of wounds in mice. The growth and migration effects of Y27632 appeared to be specific to keratinocytes compared with dermal fibroblasts, and required intact Jun kinase function. Y27632 seems to be a promising agent for keratinocyte procurement and wounding healing.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clin Exp Dermatol

DOI

EISSN

1365-2230

Publication Date

October 2013

Volume

38

Issue

7

Start / End Page

782 / 786

Location

England

Related Subject Headings

  • rho-Associated Kinases
  • Wound Healing
  • Pyridines
  • Mice
  • Keratinocytes
  • Humans
  • Enzyme Inhibitors
  • Disease Models, Animal
  • Dermatology & Venereal Diseases
  • Cells, Cultured
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gandham, V. D., Maddala, R. L., Rao, V., Jin, J. Y., Epstein, D. L., Hall, R. P., & Zhang, J. Y. (2013). Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol, 38(7), 782–786. https://doi.org/10.1111/ced.12067
Gandham, V. D., R. L. Maddala, V. Rao, J. Y. Jin, D. L. Epstein, R. P. Hall, and J. Y. Zhang. “Effects of Y27632 on keratinocyte procurement and wound healing.Clin Exp Dermatol 38, no. 7 (October 2013): 782–86. https://doi.org/10.1111/ced.12067.
Gandham VD, Maddala RL, Rao V, Jin JY, Epstein DL, Hall RP, et al. Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol. 2013 Oct;38(7):782–6.
Gandham, V. D., et al. “Effects of Y27632 on keratinocyte procurement and wound healing.Clin Exp Dermatol, vol. 38, no. 7, Oct. 2013, pp. 782–86. Pubmed, doi:10.1111/ced.12067.
Gandham VD, Maddala RL, Rao V, Jin JY, Epstein DL, Hall RP, Zhang JY. Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol. 2013 Oct;38(7):782–786.
Journal cover image

Published In

Clin Exp Dermatol

DOI

EISSN

1365-2230

Publication Date

October 2013

Volume

38

Issue

7

Start / End Page

782 / 786

Location

England

Related Subject Headings

  • rho-Associated Kinases
  • Wound Healing
  • Pyridines
  • Mice
  • Keratinocytes
  • Humans
  • Enzyme Inhibitors
  • Disease Models, Animal
  • Dermatology & Venereal Diseases
  • Cells, Cultured