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Systematic review and metasummary of attitudes toward research in emergency medical conditions.

Publication ,  Journal Article
Limkakeng, AT; de Oliveira, LLH; Moreira, T; Phadtare, A; Garcia Rodrigues, C; Hocker, MB; McKinney, R; Voils, CI; Pietrobon, R
Published in: J Med Ethics
June 2014

Emergency departments are challenging research settings, where truly informed consent can be difficult to obtain. A deeper understanding of emergency medical patients' opinions about research is needed. We conducted a systematic review and meta-summary of quantitative and qualitative studies on which values, attitudes, or beliefs of emergent medical research participants influence research participation. We included studies of adults that investigated opinions toward emergency medicine research participation. We excluded studies focused on the association between demographics or consent document features and participation and those focused on non-emergency research. In August 2011, we searched the following databases: MEDLINE, EMBASE, Google Scholar, Scirus, PsycINFO, AgeLine and Global Health. Titles, abstracts and then full manuscripts were independently evaluated by two reviewers. Disagreements were resolved by consensus and adjudicated by a third author. Studies were evaluated for bias using standardised scores. We report themes associated with participation or refusal. Our initial search produced over 1800 articles. A total of 44 articles were extracted for full-manuscript analysis, and 14 were retained based on our eligibility criteria. Among factors favouring participation, altruism and personal health benefit had the highest frequency. Mistrust of researchers, feeling like a 'guinea pig' and risk were leading factors favouring refusal. Many studies noted limitations of informed consent processes in emergent conditions. We conclude that highlighting the benefits to the participant and society, mitigating risk and increasing public trust may increase research participation in emergency medical research. New methods for conducting informed consent in such studies are needed.

Duke Scholars

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Published In

J Med Ethics

DOI

EISSN

1473-4257

Publication Date

June 2014

Volume

40

Issue

6

Start / End Page

401 / 408

Location

England

Related Subject Headings

  • Trust
  • Risk
  • Research Subjects
  • Public Opinion
  • Informed Consent
  • Humans
  • Evaluation Studies as Topic
  • Emergency Medicine
  • Clinical Trials as Topic
  • Applied Ethics
 

Citation

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Limkakeng, A. T., de Oliveira, L. L. H., Moreira, T., Phadtare, A., Garcia Rodrigues, C., Hocker, M. B., … Pietrobon, R. (2014). Systematic review and metasummary of attitudes toward research in emergency medical conditions. J Med Ethics, 40(6), 401–408. https://doi.org/10.1136/medethics-2012-101147
Limkakeng, Alexander T., Lucas Lentini Herling de Oliveira, Tais Moreira, Amruta Phadtare, Clarissa Garcia Rodrigues, Michael B. Hocker, Ross McKinney, Corrine I. Voils, and Ricardo Pietrobon. “Systematic review and metasummary of attitudes toward research in emergency medical conditions.J Med Ethics 40, no. 6 (June 2014): 401–8. https://doi.org/10.1136/medethics-2012-101147.
Limkakeng AT, de Oliveira LLH, Moreira T, Phadtare A, Garcia Rodrigues C, Hocker MB, et al. Systematic review and metasummary of attitudes toward research in emergency medical conditions. J Med Ethics. 2014 Jun;40(6):401–8.
Limkakeng, Alexander T., et al. “Systematic review and metasummary of attitudes toward research in emergency medical conditions.J Med Ethics, vol. 40, no. 6, June 2014, pp. 401–08. Pubmed, doi:10.1136/medethics-2012-101147.
Limkakeng AT, de Oliveira LLH, Moreira T, Phadtare A, Garcia Rodrigues C, Hocker MB, McKinney R, Voils CI, Pietrobon R. Systematic review and metasummary of attitudes toward research in emergency medical conditions. J Med Ethics. 2014 Jun;40(6):401–408.

Published In

J Med Ethics

DOI

EISSN

1473-4257

Publication Date

June 2014

Volume

40

Issue

6

Start / End Page

401 / 408

Location

England

Related Subject Headings

  • Trust
  • Risk
  • Research Subjects
  • Public Opinion
  • Informed Consent
  • Humans
  • Evaluation Studies as Topic
  • Emergency Medicine
  • Clinical Trials as Topic
  • Applied Ethics