Releasing the block: setting differentiation free with mutant IDH inhibitors.
Publication
, Journal Article
Pirozzi, CJ; Reitman, ZJ; Yan, H
Published in: Cancer Cell
May 13, 2013
Hotspot mutations in IDH1 and IDH2 cause a differentiation block that can promote tumorigenesis. Two recent papers reported that small molecules targeting mutant IDH1 or mutant IDH2 release this differentiation block and/or impede tumor growth, providing a proof-of-concept that mutant IDHs are therapeutically targetable and that their effects are reversible.
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Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
May 13, 2013
Volume
23
Issue
5
Start / End Page
570 / 572
Location
United States
Related Subject Headings
- Sulfonamides
- Phenylurea Compounds
- Oncology & Carcinogenesis
- Leukemia, Myeloid, Acute
- Isocitrate Dehydrogenase
- Imidazoles
- Humans
- Hematopoiesis
- Glioma
- Enzyme Inhibitors
Citation
APA
Chicago
ICMJE
MLA
NLM
Pirozzi, C. J., Reitman, Z. J., & Yan, H. (2013). Releasing the block: setting differentiation free with mutant IDH inhibitors. Cancer Cell, 23(5), 570–572. https://doi.org/10.1016/j.ccr.2013.04.024
Pirozzi, Christopher J., Zachary J. Reitman, and Hai Yan. “Releasing the block: setting differentiation free with mutant IDH inhibitors.” Cancer Cell 23, no. 5 (May 13, 2013): 570–72. https://doi.org/10.1016/j.ccr.2013.04.024.
Pirozzi CJ, Reitman ZJ, Yan H. Releasing the block: setting differentiation free with mutant IDH inhibitors. Cancer Cell. 2013 May 13;23(5):570–2.
Pirozzi, Christopher J., et al. “Releasing the block: setting differentiation free with mutant IDH inhibitors.” Cancer Cell, vol. 23, no. 5, May 2013, pp. 570–72. Pubmed, doi:10.1016/j.ccr.2013.04.024.
Pirozzi CJ, Reitman ZJ, Yan H. Releasing the block: setting differentiation free with mutant IDH inhibitors. Cancer Cell. 2013 May 13;23(5):570–572.
Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
May 13, 2013
Volume
23
Issue
5
Start / End Page
570 / 572
Location
United States
Related Subject Headings
- Sulfonamides
- Phenylurea Compounds
- Oncology & Carcinogenesis
- Leukemia, Myeloid, Acute
- Isocitrate Dehydrogenase
- Imidazoles
- Humans
- Hematopoiesis
- Glioma
- Enzyme Inhibitors