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Controversies in oral antiplatelet therapy in patients undergoing aortocoronary bypass surgery.

Publication ,  Journal Article
Mahla, E; Metzler, H; Tantry, US; Gurbel, PA
Published in: Ann Thorac Surg
September 2010

Oral antiplatelet therapy with aspirin and clopidogrel is a major strategy to prevent thrombotic events in patients with acute coronary syndromes and patients undergoing percutaneous coronary interventions. Although this therapy is associated with both short- and long-term clinical efficacy, irreversible platelet inhibition and ischemic events associated with premature withdrawal especially in patients treated with drug-eluting stents constitute a particular limitation in patients undergoing surgery. The current review article is focused on the central role of platelets in the occurrence of ischemic events, the significance of antiplatelet therapy, the potential hazards of drug withdrawal in patients needing coronary artery bypass grafting, and future perspectives.

Duke Scholars

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

September 2010

Volume

90

Issue

3

Start / End Page

1040 / 1051

Location

Netherlands

Related Subject Headings

  • Ticlopidine
  • Thrombosis
  • Thiophenes
  • Respiratory System
  • Pyridines
  • Prasugrel Hydrochloride
  • Platelet Aggregation Inhibitors
  • Piperazines
  • Humans
  • Coronary Artery Bypass
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mahla, E., Metzler, H., Tantry, U. S., & Gurbel, P. A. (2010). Controversies in oral antiplatelet therapy in patients undergoing aortocoronary bypass surgery. Ann Thorac Surg, 90(3), 1040–1051. https://doi.org/10.1016/j.athoracsur.2010.04.041
Mahla, Elisabeth, Helfried Metzler, Udaya S. Tantry, and Paul A. Gurbel. “Controversies in oral antiplatelet therapy in patients undergoing aortocoronary bypass surgery.Ann Thorac Surg 90, no. 3 (September 2010): 1040–51. https://doi.org/10.1016/j.athoracsur.2010.04.041.
Mahla E, Metzler H, Tantry US, Gurbel PA. Controversies in oral antiplatelet therapy in patients undergoing aortocoronary bypass surgery. Ann Thorac Surg. 2010 Sep;90(3):1040–51.
Mahla, Elisabeth, et al. “Controversies in oral antiplatelet therapy in patients undergoing aortocoronary bypass surgery.Ann Thorac Surg, vol. 90, no. 3, Sept. 2010, pp. 1040–51. Pubmed, doi:10.1016/j.athoracsur.2010.04.041.
Mahla E, Metzler H, Tantry US, Gurbel PA. Controversies in oral antiplatelet therapy in patients undergoing aortocoronary bypass surgery. Ann Thorac Surg. 2010 Sep;90(3):1040–1051.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

September 2010

Volume

90

Issue

3

Start / End Page

1040 / 1051

Location

Netherlands

Related Subject Headings

  • Ticlopidine
  • Thrombosis
  • Thiophenes
  • Respiratory System
  • Pyridines
  • Prasugrel Hydrochloride
  • Platelet Aggregation Inhibitors
  • Piperazines
  • Humans
  • Coronary Artery Bypass