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Uniform platelet activation exists before coronary stent implantation despite aspirin therapy.

Publication ,  Journal Article
Serebruany, VL; Cummings, CC; Malinin, AI; Steinhubl, SR; Gurbel, PA
Published in: Am Heart J
October 2001

BACKGROUND: Platelets play an important role in the natural history of coronary artery disease. Enhanced platelet aggregation and receptor expression unquestionably occur after coronary stent implantation; however, the functional characteristics of platelets before stenting have not been fully elucidated. METHODS: Platelets were assessed before intervention by platelet-rich plasma aggregation (PA) with 5 mmol adenosine diphosphate (ADP) and 1 mg/mL collagen; whole blood aggregation (WBA) by 1 mg/mL collagen; shear-induced closure time (CT); contractile force (CF); and expression of 9 surface receptors by flow cytometry in 126 patients undergoing elective coronary artery stent placement. All patients received aspirin for at least 7 days. The data were compared with those from 64 healthy volunteers. RESULTS: Each test revealed sustained platelet activation in patients undergoing coronary stenting compared with control values. These differences were significant for collagen-induced PA (P =.031); CF (P =.0001); expression of glycoprotein (GP) IIb/IIIa (P =.0001); P-selectin (P =.0008); platelet/endothelial cell adhesion molecule (PECAM)-1 (P =.0001); CD107a (P =.0001); CD107b (P =.0004); and CD63 (P =.009). CONCLUSION: Platelets are indeed activated before coronary stenting despite antecedent therapy with aspirin.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

October 2001

Volume

142

Issue

4

Start / End Page

611 / 616

Location

United States

Related Subject Headings

  • Stents
  • Preoperative Care
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Platelet Activation
  • Middle Aged
  • Male
  • Humans
  • Female
  • Coronary Vessels
 

Citation

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Serebruany, V. L., Cummings, C. C., Malinin, A. I., Steinhubl, S. R., & Gurbel, P. A. (2001). Uniform platelet activation exists before coronary stent implantation despite aspirin therapy. Am Heart J, 142(4), 611–616. https://doi.org/10.1067/mhj.2001.116478
Serebruany, V. L., C. C. Cummings, A. I. Malinin, S. R. Steinhubl, and P. A. Gurbel. “Uniform platelet activation exists before coronary stent implantation despite aspirin therapy.Am Heart J 142, no. 4 (October 2001): 611–16. https://doi.org/10.1067/mhj.2001.116478.
Serebruany VL, Cummings CC, Malinin AI, Steinhubl SR, Gurbel PA. Uniform platelet activation exists before coronary stent implantation despite aspirin therapy. Am Heart J. 2001 Oct;142(4):611–6.
Serebruany, V. L., et al. “Uniform platelet activation exists before coronary stent implantation despite aspirin therapy.Am Heart J, vol. 142, no. 4, Oct. 2001, pp. 611–16. Pubmed, doi:10.1067/mhj.2001.116478.
Serebruany VL, Cummings CC, Malinin AI, Steinhubl SR, Gurbel PA. Uniform platelet activation exists before coronary stent implantation despite aspirin therapy. Am Heart J. 2001 Oct;142(4):611–616.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

October 2001

Volume

142

Issue

4

Start / End Page

611 / 616

Location

United States

Related Subject Headings

  • Stents
  • Preoperative Care
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Platelet Activation
  • Middle Aged
  • Male
  • Humans
  • Female
  • Coronary Vessels