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Soluble PECAM-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain.

Publication ,  Journal Article
Serebruany, VL; Murugesan, SR; Pothula, A; Semaan, H; Gurbel, PA
Published in: Cardiology
1999

We sought to determine plasma levels of platelet/endothelial cell adhesion molecule-1 (PECAM-1), P-selectin, and platelet-derived osteonectin, and prospectively compare these data with the discharge diagnosis in patients presenting with chest pain in a community hospital Emergency Department. Soluble antigens were measured by ELISA in 44 subjects including patients with acute myocardial infarction (AMI) (n = 13), chest pain of noncardiac origin (n = 17), and compared to those of age- and sex-matched healthy controls (n = 14). Elevated soluble PECAM-1 (64.5 +/- 18.3 ng/ml, p = 0.019), but not P-selectin (149.5 +/- 49.8 ng/ml, p = NS), nor osteonectin (549. 5 +/- 159.1 ng/ml, p = NS), occurred in the AMI group as compared to patients with noncardiac chest pain (46.2 +/- 7.5 ng/ml, 118.2 +/- 40.1 ng/ml, and 619.4 +/- 74.4 ng/ml, respectively). Increased plasma PECAM-1 may serve as a useful marker in the early detection of patients with AMI. Larger studies will be necessary to confirm the utility of soluble PECAM-1 in identifying AMI among patients presenting with chest pain.

Duke Scholars

Published In

Cardiology

DOI

ISSN

0008-6312

Publication Date

1999

Volume

91

Issue

1

Start / End Page

50 / 55

Location

Switzerland

Related Subject Headings

  • Prospective Studies
  • Predictive Value of Tests
  • Platelet Endothelial Cell Adhesion Molecule-1
  • P-Selectin
  • Osteonectin
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Serebruany, V. L., Murugesan, S. R., Pothula, A., Semaan, H., & Gurbel, P. A. (1999). Soluble PECAM-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain. Cardiology, 91(1), 50–55. https://doi.org/10.1159/000006876
Serebruany, V. L., S. R. Murugesan, A. Pothula, H. Semaan, and P. A. Gurbel. “Soluble PECAM-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain.Cardiology 91, no. 1 (1999): 50–55. https://doi.org/10.1159/000006876.
Serebruany VL, Murugesan SR, Pothula A, Semaan H, Gurbel PA. Soluble PECAM-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain. Cardiology. 1999;91(1):50–5.
Serebruany, V. L., et al. “Soluble PECAM-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain.Cardiology, vol. 91, no. 1, 1999, pp. 50–55. Pubmed, doi:10.1159/000006876.
Serebruany VL, Murugesan SR, Pothula A, Semaan H, Gurbel PA. Soluble PECAM-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain. Cardiology. 1999;91(1):50–55.
Journal cover image

Published In

Cardiology

DOI

ISSN

0008-6312

Publication Date

1999

Volume

91

Issue

1

Start / End Page

50 / 55

Location

Switzerland

Related Subject Headings

  • Prospective Studies
  • Predictive Value of Tests
  • Platelet Endothelial Cell Adhesion Molecule-1
  • P-Selectin
  • Osteonectin
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans
  • Female