Skip to main content
Journal cover image

Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction.

Publication ,  Journal Article
Serebruany, VL; Gurbel, PA; Murugesan, SR; Lowry, DR; Sturm, E; Svetlov, SI
Published in: Cardiology
October 1998

Cell membrane phospholipids, including platelet-activating factor (PAF), participate in the pathogenesis of acute myocardial infarction (AMI). The plasma level of PAF acetylhydrolase (AH) was determined in 18 patients at presentation with AMI before thrombolysis, and the administration of adjunctive therapy, and compared with 13 healthy controls. Plasma levels of PAF-AH were significantly lower in the AMI patients (23.15 +/- 1.75 nmol/min/ml) than in the controls (30.43 +/- 2.13 nmol/min/ml; p = 0.027). Considering normal plasma levels of PAF and lyso-PAF, and lack of evidence that anti-PAF antibodies are really beneficial in myocardial ischemia-reperfusion, it is reasonable to speculate that an inability of systemic PAF to 'turn on' PAF-AH enzymatic activity could contribute substantially to the observed events. Decreased PAF-AH activity in AMI patients may represent not a consequence, but rather, a risk factor for the development of acute coronary syndromes.

Duke Scholars

Published In

Cardiology

DOI

ISSN

0008-6312

Publication Date

October 1998

Volume

90

Issue

2

Start / End Page

127 / 130

Location

Switzerland

Related Subject Headings

  • Thrombolytic Therapy
  • Severity of Illness Index
  • Platelet Activating Factor
  • Phospholipases A
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans
  • Fibrinolytic Agents
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Serebruany, V. L., Gurbel, P. A., Murugesan, S. R., Lowry, D. R., Sturm, E., & Svetlov, S. I. (1998). Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction. Cardiology, 90(2), 127–130. https://doi.org/10.1159/000006831
Serebruany, V. L., P. A. Gurbel, S. R. Murugesan, D. R. Lowry, E. Sturm, and S. I. Svetlov. “Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction.Cardiology 90, no. 2 (October 1998): 127–30. https://doi.org/10.1159/000006831.
Serebruany VL, Gurbel PA, Murugesan SR, Lowry DR, Sturm E, Svetlov SI. Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction. Cardiology. 1998 Oct;90(2):127–30.
Serebruany, V. L., et al. “Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction.Cardiology, vol. 90, no. 2, Oct. 1998, pp. 127–30. Pubmed, doi:10.1159/000006831.
Serebruany VL, Gurbel PA, Murugesan SR, Lowry DR, Sturm E, Svetlov SI. Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction. Cardiology. 1998 Oct;90(2):127–130.
Journal cover image

Published In

Cardiology

DOI

ISSN

0008-6312

Publication Date

October 1998

Volume

90

Issue

2

Start / End Page

127 / 130

Location

Switzerland

Related Subject Headings

  • Thrombolytic Therapy
  • Severity of Illness Index
  • Platelet Activating Factor
  • Phospholipases A
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Humans
  • Fibrinolytic Agents
  • Female